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    Cox7a1 cytochrome c oxidase subunit 7A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687508, updated on 27-Dec-2024

    Summary

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    Symbol
    Cox7a1provided by RGD
    Full Name
    cytochrome c oxidase subunit 7A1provided by RGD
    Primary source
    RGD:6496527
    See related
    EnsemblRapid:ENSRNOG00000076290 AllianceGenome:RGD:6496527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex. Orthologous to human COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 166.1), Lung (RPKM 111.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox7a1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94549663..94572330)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85422162..85447530)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91070593..91096190, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 382 Neighboring gene zinc finger protein 146 Neighboring gene prothymosin alpha, pseudogene 5 Neighboring gene ribosomal protein S24, pseudogene 2 Neighboring gene calpain, small subunit 1 Neighboring gene U2 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 826

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of oxidative phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of respiratory chain complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 7A1
    Names
    cytochrome c oxidase subunit 7A1, mitochondrial
    cytochrome c oxidase subunit 7A1, mitochondrial-like
    cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402200.1 → NP_001389129.1  cytochrome c oxidase subunit 7A1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J9U1, M0R5K3, M0RAY3
      Related
      ENSRNOP00000101597.1, ENSRNOT00000146299.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94549663..94572330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274198.1 → XP_063130268.1  cytochrome c oxidase subunit 7A1 isoform X1

    2. XM_063274204.1 → XP_063130274.1  cytochrome c oxidase subunit 7A1 isoform X3

      UniProtKB/TrEMBL
      M0R5K3, M0RAY3

    3. XM_063274200.1 → XP_063130270.1  cytochrome c oxidase subunit 7A1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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