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    Neurl1b neuralized E3 ubiquitin protein ligase 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303019, updated on 9-Dec-2024

    Summary

    Official Symbol
    Neurl1bprovided by RGD
    Official Full Name
    neuralized E3 ubiquitin protein ligase 1Bprovided by RGD
    Primary source
    RGD:1564984
    See related
    EnsemblRapid:ENSRNOG00000027606 AllianceGenome:RGD:1564984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Neurl2; RGD1564984
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Predicted to be located in actin cytoskeleton and cytosol. Predicted to be active in early endosome. Orthologous to human NEURL1B (neuralized E3 ubiquitin protein ligase 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 58.3), Adrenal (RPKM 58.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Neurl1b in Genome Data Viewer
    Location:
    10q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (17258317..17289362, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (16754002..16785049, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (17048251..17075139, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552476 Neighboring gene dual specificity phosphatase 1 Neighboring gene uncharacterized LOC102555877 Neighboring gene transmembrane protein 134, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    located_in actin cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    is_active_in early endosome  
    located_in early endosome  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NEURL1B
    Names
    E3 ubiquitin-protein ligase NEURL3
    neuralized 2
    NP_001136124.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142652.3NP_001136124.1  E3 ubiquitin-protein ligase NEURL1B

      See identical proteins and their annotated locations for NP_001136124.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      C9DQJ9, F7F6Y2
      Related
      ENSRNOP00000078155.1, ENSRNOT00000119281.2
      Conserved Domains (4) summary
      smart00588
      Location:40159
      NEUZ; domain in neuralized proteins
      pfam07177
      Location:41106
      Neuralized; Neuralized
      pfam13920
      Location:490540
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl02614
      Location:40189
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      17258317..17289362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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