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    Otud7a OTU deubiquitinase 7A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309252, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Otud7aprovided by RGD
    Official Full Name
    OTU deubiquitinase 7Aprovided by RGD
    Primary source
    RGD:1563721
    See related
    EnsemblRapid:ENSRNOG00000015503 AllianceGenome:RGD:1563721
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563721
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Predicted to be involved in protein K11-linked deubiquitination and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human OTUD7A (OTU deubiquitinase 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 64.1), Lung (RPKM 24.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Otud7a in Genome Data Viewer
    Location:
    1q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (126476275..126800037)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117064428..117388217)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (124311873..124655437)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548165 Neighboring gene uncharacterized LOC102548323 Neighboring gene ribosomal protein L36, pseudogene Neighboring gene high mobility group nucleosome binding domain 5B Neighboring gene ribosomal protein L7a, pseudogene 34 Neighboring gene uncharacterized LOC134483597 Neighboring gene small nucleolar RNA U3 Neighboring gene KLF transcription factor 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Mevissen TE, et al. Cell, 2013 Jul 3. PMID 23827681, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    OTU domain-containing protein 7A
    Names
    OTU domain containing 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      126476275..126800037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278750.1 → XP_063134820.1  OTU domain-containing protein 7A isoform X1

      UniProtKB/TrEMBL
      D4ABZ4

    2. XM_008759566.4 → XP_008757788.1  OTU domain-containing protein 7A isoform X3

      See identical proteins and their annotated locations for XP_008757788.1

      UniProtKB/TrEMBL
      D4ABZ4
      Related
      ENSRNOP00000110596.1, ENSRNOT00000139392.1
      Conserved Domains (3) summary
      cd14347
      Location:26 → 68
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:899 → 922
      zf-A20; A20-like zinc finger
      cl19932
      Location:207 → 378
      OTU; OTU-like cysteine protease

    3. XM_063278759.1 → XP_063134829.1  OTU domain-containing protein 7A isoform X2

      UniProtKB/TrEMBL
      D4ABZ4

    4. XM_008759568.4 → XP_008757790.1  OTU domain-containing protein 7A isoform X4

      UniProtKB/TrEMBL
      D4ABZ4
      Conserved Domains (3) summary
      cd14347
      Location:26 → 68
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:898 → 921
      zf-A20; A20-like zinc finger
      cl19932
      Location:206 → 377
      OTU; OTU-like cysteine protease

    5. XM_063278751.1 → XP_063134821.1  OTU domain-containing protein 7A isoform X1

      UniProtKB/TrEMBL
      D4ABZ4

    6. XM_063278757.1 → XP_063134827.1  OTU domain-containing protein 7A isoform X1

      UniProtKB/TrEMBL
      D4ABZ4
    Nucleotide Protein Strain
    Heading Accession and Version

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