Kifap3 kinesin-associated protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kifap3provided by RGD
Official Full Name: kinesin-associated protein 3provided by RGD
Primary source: RGD:1305191
See related: EnsemblRapid:ENSRNOG00000002544 AllianceGenome:RGD:1305191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable intraciliary transport particle B binding activity; kinesin binding activity; and protein phosphatase binding activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex and cilium organization. Predicted to act upstream of or within several processes, including negative regulation of apoptotic process; negative regulation of neuroblast proliferation; and positive regulation of calcium-dependent cell-cell adhesion. Predicted to be located in several cellular components, including microtubule cytoskeleton; periciliary membrane compartment; and photoreceptor cell cilium. Predicted to be part of kinesin II complex. Predicted to be active in several cellular components, including axoneme; ciliary transition zone; and glutamatergic synapse. Orthologous to human KIFAP3 (kinesin associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 471.5), Testes (RPKM 224.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (78660849..78797821)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (76127702..76264654)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (82072497..82217256)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA interference screening of kinesin genes identifies Kif1a, a member of the kinesin-3 family, as the motor for basally directed nuclear movement in neural stem cells.
Title: Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells.
Results support the view that decreased KAP3 synthesis diminishes GnRH output and delays female sexual development by compromising hypothalamic release of glutamate.
Title: Kinesin superfamily-associated protein 3 is preferentially expressed in glutamatergic neurons and contributes to the excitatory control of female puberty.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_15739-15740:1013613501:1 (e-PCR)
- UniSTS:267889

AA850497 (e-PCR)
- UniSTS:261495

RH130610 (e-PCR)
- UniSTS:213894

RH141990 (e-PCR)
- UniSTS:223981

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables intraciliary transport particle B binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of neurotransmitter receptor complex	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cilium organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium-dependent cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
is_active_in ciliary transition zone	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of kinesin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin II complex	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in periciliary membrane compartment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401347.1 → NP_001388276.1 kinesin-associated protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I5ZXB9

Related

ENSRNOP00000082498.2, ENSRNOT00000112619.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

78660849..78797821

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090489.2 → XP_038946417.1 kinesin-associated protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2K0P1, A0A8I5ZXB9

Related

ENSRNOP00000093594.2, ENSRNOT00000095640.2

Conserved Domains (1) summary

pfam05804
Location:29 → 736

KAP; Kinesin-associated protein (KAP)
XM_039090490.2 → XP_038946418.1 kinesin-associated protein 3 isoform X2

UniProtKB/TrEMBL

A6IDC5, D3ZWA5

Related

ENSRNOP00000071523.3, ENSRNOT00000085135.3

Conserved Domains (1) summary

pfam05804
Location:29 → 736

KAP; Kinesin-associated protein (KAP)
XM_063272116.1 → XP_063128186.1 kinesin-associated protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I5ZXB9

Related

ENSRNOP00000063896.5, ENSRNOT00000063810.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001105964.1: Suppressed sequence

Description

NM_001105964.1: This RefSeq was removed because currently there is insufficient support for the transcript.