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    Rad18 RAD18 E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362412, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rad18provided by RGD
    Official Full Name
    RAD18 E3 ubiquitin protein ligaseprovided by RGD
    Primary source
    RGD:1306993
    See related
    EnsemblRapid:ENSRNOG00000005907 AllianceGenome:RGD:1306993
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including Y-form DNA binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of chromosome segregation; postreplication repair; and protein monoubiquitination. Predicted to act upstream of or within several processes, including negative regulation of DNA recombination; protein autoubiquitination; and response to UV. Predicted to be located in centrosome; chromosome; and nucleus. Predicted to be part of Rad6-Rad18 complex. Predicted to be active in nucleus. Orthologous to human RAD18 (RAD18 E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 140.0), Thymus (RPKM 68.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rad18 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (147291463..147376904, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (145735654..145821102, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (144537329..144620606, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene caveolin 3 Neighboring gene oxytocin receptor Neighboring gene uncharacterized LOC102548080 Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC156682

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Y-form DNA binding  
    enables identical protein binding  
    enables metal ion binding  
    enables polyubiquitin modification-dependent protein binding  
    enables protein-containing complex binding  
    enables single-stranded DNA binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase binding  
    Component Evidence Code Pubs
    part_of Rad6-Rad18 complex  
    located_in XY body  
    located_in centrosome  
    located_in chromatin  
    located_in male germ cell nucleus  
    located_in nuclear body  
    located_in nuclear body  
    located_in nuclear inclusion body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in replication fork  
    located_in site of double-strand break  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RAD18
    Names
    RAD18 homolog
    NP_001071141.1
    XP_006237098.1
    XP_006237099.1
    XP_063142360.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077673.1NP_001071141.1  E3 ubiquitin-protein ligase RAD18

      See identical proteins and their annotated locations for NP_001071141.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127510
      UniProtKB/TrEMBL
      A0A8I5YBD2, A0JPN0
      Related
      ENSRNOP00000063400.1, ENSRNOT00000066468.4
      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13363
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      147291463..147376904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286290.1XP_063142360.1  E3 ubiquitin-protein ligase RAD18 isoform X3

      UniProtKB/TrEMBL
      A6IBN3
      Related
      ENSRNOP00000076533.2, ENSRNOT00000099439.2
    2. XM_006237036.4XP_006237098.1  E3 ubiquitin-protein ligase RAD18 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBD2
      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13363
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain
    3. XM_006237037.4XP_006237099.1  E3 ubiquitin-protein ligase RAD18 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKR5, A6IBN3
      Related
      ENSRNOP00000094440.1, ENSRNOT00000115978.2
      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13363
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain
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