Tpi1 triosephosphate isomerase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tpi1provided by RGD
Full Name: triosephosphate isomerase 1provided by RGD
Primary source: RGD:3896
See related: EnsemblRapid:ENSRNOG00000015290 AllianceGenome:RGD:3896
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tpi
Summary: Enables triose-phosphate isomerase activity. Predicted to be involved in several processes, including glucose metabolic process; glyceraldehyde-3-phosphate biosynthetic process; and methylglyoxal biosynthetic process. Predicted to act upstream of or within glucose metabolic process. Predicted to be active in cytosol. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 12880.2), Heart (RPKM 3327.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (159301558..159305088, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (157615283..157618813, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (157328375..157331905, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples.
Title: Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples.
Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls.
Title: The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.
glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex, including Kir6.2, and regulate its function
Title: The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129184 (e-PCR)
- UniSTS:212492

AI255506 (e-PCR)
- UniSTS:165488

AI411387 (e-PCR)
- UniSTS:250507

RH94523 (e-PCR)
- UniSTS:119771

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables isomerase activity	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables methylglyoxal synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables triose-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triose-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables triose-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables triose-phosphate isomerase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glyceraldehyde-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glyceraldehyde-3-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	TAS Traceable Author Statement more info	PubMed
involved_in methylglyoxal biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: triosephosphate isomerase

Names: TIM; methylglyoxal synthase; triose-phosphate isomerase; triosephosphate isomerase-like

NP_075211.2

EC 4.2.3.3

EC 5.3.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.