Slc3a1 solute carrier family 3 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc3a1provided by RGD
Official Full Name: solute carrier family 3 member 1provided by RGD
Primary source: RGD:3709
See related: EnsemblRapid:ENSRNOG00000007006 AllianceGenome:RGD:3709
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NBAT; rBAT
Summary: Predicted to enable protein heterodimerization activity. Involved in amino acid transport. Located in vacuolar membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 7324.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (15361037..15396695, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (9608169..9641881, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (8284937..8318649)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D2S2946 (e-PCR)
- UniSTS:474531

AW535278 (e-PCR)
- UniSTS:247211

RH132752 (e-PCR)
- UniSTS:216035

RH139082 (e-PCR)
- UniSTS:221168

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-cystine transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amino acid transporter heavy chain SLC3A1

Names: D2; NAA-TR; b(0,+)-type amino acid transport protein; b(0,+)-type amino acid transporter-related heavy chain; neutral and basic amino acid transport protein rBAT; neutral and basic amino acid transporter protein; solute carrier family 3 (amino acid transporter heavy chain), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017216.1 → NP_058912.1 amino acid transporter heavy chain SLC3A1

See identical proteins and their annotated locations for NP_058912.1

Status: PROVISIONAL

Source sequence(s)

M77345

UniProtKB/Swiss-Prot

Q62672, Q64319

UniProtKB/TrEMBL

A6H9H4

Related

ENSRNOP00000009581.2, ENSRNOT00000009581.6

Conserved Domains (1) summary

cd11359
Location:113 → 566

AmyAc_SLC3A1; Alpha amylase catalytic domain found in Solute Carrier family 3 member 1 proteins