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    Cdk4 cyclin-dependent kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94201, updated on 4-Jan-2025

    Summary

    Symbol
    Cdk4provided by RGD
    Full Name
    cyclin-dependent kinase 4provided by RGD
    Primary source
    RGD:621120
    See related
    AllianceGenome:RGD:621120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to polyamine macromolecule; positive regulation of cell size; and response to testosterone. Located in nucleus and perinuclear region of cytoplasm. Biomarker of hepatocellular carcinoma; pancreatic cancer; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 573.2), Adrenal (RPKM 371.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cdk4 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64771453..64774891)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62886124..62889562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70345971..70352689)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane associated ring-CH-type finger 9 Neighboring gene tetraspanin 31 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Neighboring gene OS9, endoplasmic reticulum lectin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables cyclin binding  
    enables cyclin binding  
    enables cyclin binding PubMed 
    enables cyclin binding  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle PubMed 
    involved_in animal organ regeneration PubMed 
    involved_in cell division  
    acts_upstream_of_or_within cellular response to interleukin-4  
    acts_upstream_of_or_within cellular response to ionomycin  
    acts_upstream_of_or_within cellular response to lipopolysaccharide  
    acts_upstream_of_or_within cellular response to phorbol 13-acetate 12-myristate  
    involved_in cellular response to polyamine macromolecule PubMed 
    involved_in circadian rhythm PubMed 
    involved_in lens development in camera-type eye PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell size PubMed 
    involved_in positive regulation of epithelial cell proliferation PubMed 
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of translation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of G2/M transition of mitotic cell cycle  
    acts_upstream_of_or_within regulation of cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of gene expression  
    involved_in regulation of gene expression  
    involved_in regulation of gene expression  
    acts_upstream_of_or_within regulation of type B pancreatic cell proliferation  
    involved_in response to hyperoxia PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to toxic substance PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in response to xenobiotic stimulus  
    involved_in signal transduction  
    acts_upstream_of_or_within signal transduction  
    Items 1 - 25 of 40
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    located_in bicellular tight junction  
    located_in chromatin  
    located_in chromatin  
    part_of cyclin D1-CDK4 complex  
    part_of cyclin D1-CDK4 complex  
    part_of cyclin D2-CDK4 complex  
    part_of cyclin D2-CDK4 complex  
    part_of cyclin D3-CDK4 complex  
    part_of cyclin D3-CDK4 complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    part_of transcription regulator complex  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    cyclin-dependent kinase 4
    Names
    PSK-J3
    cell division protein kinase 4
    NP_001389324.1
    NP_446045.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402395.1NP_001389324.1  cyclin-dependent kinase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
    2. NM_053593.3NP_446045.1  cyclin-dependent kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_446045.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P35426
      UniProtKB/TrEMBL
      A0A8L2QI74, A6HQS0
      Conserved Domains (1) summary
      cl21453
      Location:5295
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64771453..64774891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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