Nmrk2 nicotinamide riboside kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nmrk2provided by RGD
Official Full Name: nicotinamide riboside kinase 2provided by RGD
Primary source: RGD:6486791
See related: EnsemblRapid:ENSRNOG00000042897 AllianceGenome:RGD:6486791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Predicted to act upstream of or within negative regulation of myoblast differentiation. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 420.3), Heart (RPKM 176.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9165567..9168638)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8514855..8517916)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11382966..11386170)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ribosylnicotinamide kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosylnicotinate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nicotinamide riboside kinase 2

XP_003750325.2

EC 2.7.1.-

EC 2.7.1.173

EC 2.7.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432213.1 → NP_001419142.1 nicotinamide riboside kinase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6K8B4, D3ZBU8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9165567..9168638

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003750277.6 → XP_003750325.2 nicotinamide riboside kinase 2

UniProtKB/TrEMBL

D3ZBU8

Related

ENSRNOP00000062386.4, ENSRNOT00000066348.5

Conserved Domains (1) summary

cd02024
Location:38 → 197

NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...