Trim17 tripartite motif-containing 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim17provided by RGD
Official Full Name: tripartite motif-containing 17provided by RGD
Primary source: RGD:69290
See related: EnsemblRapid:ENSRNOG00000022983 AllianceGenome:RGD:69290
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rnf16
Summary: Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including autophagy; innate immune response; and protein autoubiquitination. Predicted to be located in lysosome. Predicted to be active in cytosol. Orthologous to human TRIM17 (tripartite motif containing 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 214.4) and Brain (RPKM 7.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44242688..44250504)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (43743111..43750929)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45307007..45314823)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UV-damage excision repair	IEA Inferred from Electronic Annotation more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome disassembly	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM17

Names: RING finger protein terf; RING-type E3 ubiquitin transferase TRIM17; ring finger protein 16; testis RING finger protein; tripartite motif protein 17; tripartite motif-containing protein 17

NP_073635.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022798.2 → NP_073635.1 E3 ubiquitin-protein ligase TRIM17

See identical proteins and their annotated locations for NP_073635.1

Status: PROVISIONAL

Source sequence(s)

BC078819

UniProtKB/Swiss-Prot

Q9WV59

UniProtKB/TrEMBL

A0A0H2UI13, A6HEW7

Related

ENSRNOP00000003885.3, ENSRNOT00000003885.7

Conserved Domains (4) summary

smart00336
Location:94 → 135

BBOX; B-Box-type zinc finger

cd15812
Location:296 → 472

SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)

cl08022
Location:134 → 245

Spore_III_AB; Stage III sporulation protein AB (spore_III_AB)

cl17238
Location:16 → 65

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...