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    Sparc secreted protein acidic and cysteine rich [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24791, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sparcprovided by RGD
    Official Full Name
    secreted protein acidic and cysteine richprovided by RGD
    Primary source
    RGD:3742
    See related
    EnsemblRapid:ENSRNOG00000012840 AllianceGenome:RGD:3742
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium ion binding activity. Involved in several processes, including response to L-ascorbic acid; response to cAMP; and response to lead ion. Located in extracellular space and vesicle. Is active in glutamatergic synapse. Biomarker of diabetic angiopathy; membranoproliferative glomerulonephritis; membranous glomerulonephritis; myocardial infarction; and stomach carcinoma. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 5728.7), Heart (RPKM 5380.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sparc in Genome Data Viewer
    Location:
    10q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (40017065..40038816, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (39516394..39538252, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40742390..40764232, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 2 Neighboring gene uncharacterized LOC120095103 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene antioxidant 1 copper chaperone

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in inner ear development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ossification IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synapse organization EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to L-ascorbic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to gravity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in semicircular canal morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in platelet alpha granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in platelet alpha granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SPARC
    Names
    BM-40
    ON
    Secreted acidic cystein-rich glycoprotein (osteonectin)
    basement-membrane protein 40
    osteonectin
    secreted acidic cysteine rich glycoprotein
    secreted protein acidic and rich in cysteine
    secreted protein, acidic, cysteine-rich (osteonectin)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012656.2NP_036788.1  SPARC precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O08953, P16975, Q6GSZ4
      UniProtKB/TrEMBL
      A0A8I6ALJ7, A6HEL9
      Related
      ENSRNOP00000017486.5, ENSRNOT00000017486.9
      Conserved Domains (2) summary
      cd01328
      Location:69150
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      cd16235
      Location:153292
      EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      40017065..40038816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)