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    Tagln transgelin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taglnprovided by RGD
    Official Full Name
    transgelinprovided by RGD
    Primary source
    RGD:3723
    See related
    EnsemblRapid:ENSRNOG00000017628 AllianceGenome:RGD:3723
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sm22
    Summary
    Predicted to enable actin filament binding activity and protein-macromolecule adaptor activity. Involved in cellular response to platelet-derived growth factor stimulus. Predicted to be located in cytoplasm. Orthologous to human TAGLN (transgelin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 5700.2), Lung (RPKM 1185.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tagln in Genome Data Viewer
    Location:
    8q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55121647..55127121, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46224939..46230413, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50222895..50228369, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene beta-secretase 1 Neighboring gene ring finger protein 214 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene uncharacterized LOC120094332 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 Neighboring gene ribosomal protein S26, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-walled carbon nanotubes promote rat vascular adventitial fibroblasts to transform into myofibroblasts by SM22-α expression. Lin Z, et al. Int J Nanomedicine, 2012. PMID 22904629, Free PMC Article
    2. Microarray and bioinformatics analysis of gene expression in experimental membranous nephropathy. Hauser PV, et al. Nephron Exp Nephrol, 2009. PMID 19390219, Free PMC Article
    3. SM22alpha: the novel phenotype marker of injured glomerular epithelial cells in anti-glomerular basement membrane nephritis. Ogawa A, et al. Nephron Exp Nephrol, 2007. PMID 17519556
    4. Expression of SM22α (transgelin) in glomerular and interstitial renal injury. Inomata S, et al. Nephron Exp Nephrol, 2011. PMID 20924204
    5. [The molecular mechanisms of SM22alpha in cytoskeleton remodeling of vascular smooth muscle cells]. Wen JK, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2008 Nov. PMID 21158134

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SM22 concentrations were significantly elevated in rats from 4 hours of mesenteric ischemia onwards. Furthermore, SM22 plasma concentrations closely paralleled the histological increasing degree of intestinal smooth muscle damage.
      Title: SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia.
    2. CKII-SIRT1-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells.
      Title: CKII-SIRT1-SM22α loop evokes a self-limited inflammatory response in vascular smooth muscle cells.
    3. transgelin is up-regulated in the obstructive nephropathy
      Title: Transgelin Up-Regulation in Obstructive Nephropathy.
    4. Enhancements in smooth muscle cell properties such as transgelin expression and actomyosin-mediated contractility/motility might be involved in cell survival after NaHS exposure.
      Title: Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation.
    5. SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.
      Title: SM22α inhibits vascular inflammation via stabilization of IκBα in vascular smooth muscle cells.
    6. TRAF6-SM22alpha-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.
      Title: TRAF6-Mediated SM22α K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo.
    7. Speculate that SM22 plays an important role in the regulation of intestinal smooth muscle basal tone via Rho kinase-induced phosphorylation of SM22.
      Title: Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle.
    8. Sm22 is present in the cervix of virgin, 11 day, and 20 day pregnant rats.
      Title: The persistence of active smooth muscle in the female rat cervix through pregnancy.
    9. Investigated the role of the TGF-beta receptor and its downstream Smad signaling components that regulate SM22-alpha expression in response to SWCNT induction of VAF differentiation into MFs.
      Title: Single-walled carbon nanotubes promote rat vascular adventitial fibroblasts to transform into myofibroblasts by SM22-α expression.
    10. Data show that inhibition of SM22alpha phosphorylation abolished the Ang II-activated PKCdelta-p47phox axis and inhibited the hypertrophy and hyperplasia of vascular smooth muscle cells (VSMCs) in vitro and in vivo.
      Title: Phosphorylation of smooth muscle 22α facilitates angiotensin II-induced ROS production via activation of the PKCδ-P47phox axis through release of PKCδ and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in vitro and in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transgelin
    Names
    SM22-alpha
    smooth muscle 22 protein
    smooth muscle protein 22-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031549.2 → NP_113737.1  transgelin

      See identical proteins and their annotated locations for NP_113737.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061770
      UniProtKB/Swiss-Prot
      P31232
      UniProtKB/TrEMBL
      A0A0G2JWK7, A6J463
      Related
      ENSRNOP00000024030.5, ENSRNOT00000024030.8
      Conserved Domains (2) summary
      pfam00402
      Location:175 → 199
      Calponin; Calponin family repeat
      cd21279
      Location:23 → 143
      CH_TAGLN; calponin homology (CH) domain found in transgelin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55121647..55127121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31232.2 GenPept UniProtKB/Swiss-Prot:P31232

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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