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    Ptgs2 prostaglandin-endoperoxide synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29527, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptgs2provided by RGD
    Official Full Name
    prostaglandin-endoperoxide synthase 2provided by RGD
    Primary source
    RGD:620349
    See related
    EnsemblRapid:ENSRNOG00000002525 AllianceGenome:RGD:620349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cox2; COX-2; PGHS-2; PHS II
    Summary
    Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in caveola and cytoplasm. Part of protein-containing complex. Used to study several diseases, including brain disease (multiple); hypertension (multiple); liver disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); avian influenza; liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 161.3), Brain (RPKM 53.0) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Ptgs2 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (64714063..64722320)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (62163936..62172193)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (67351230..67356920)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 208, pseudogene 1 Neighboring gene prostaglandin-endoperoxide synthase 2, opposite strand Neighboring gene monooxygenase like, pseudogene 1 Neighboring gene phosducin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 74
    Process Evidence Code Pubs
    involved_in angiogenesis PubMed 
    acts_upstream_of_or_within bone mineralization PubMed 
    involved_in brown fat cell differentiation  
    involved_in cellular oxidant detoxification  
    involved_in cellular response to ATP PubMed 
    acts_upstream_of_or_within cellular response to fluid shear stress  
    involved_in cellular response to heat PubMed 
    involved_in cellular response to homocysteine PubMed 
    involved_in cellular response to hypoxia  
    involved_in cellular response to lead ion PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to non-ionic osmotic stress  
    involved_in cyclooxygenase pathway  
    acts_upstream_of_or_within cyclooxygenase pathway  
    involved_in cyclooxygenase pathway  
    involved_in cyclooxygenase pathway  
    involved_in decidualization PubMed 
    acts_upstream_of_or_within decidualization  
    involved_in embryo implantation PubMed 
    acts_upstream_of_or_within embryo implantation  
    involved_in hair cycle PubMed 
    involved_in learning PubMed 
    involved_in maintenance of blood-brain barrier PubMed 
    involved_in memory PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of calcium ion transport PubMed 
    involved_in negative regulation of cell cycle PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  
    involved_in negative regulation of smooth muscle contraction PubMed 
    involved_in negative regulation of synaptic transmission, dopaminergic PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of brown fat cell differentiation  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of fever generation PubMed 
    involved_in positive regulation of fever generation  
    involved_in positive regulation of fibroblast growth factor production PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of platelet-derived growth factor production PubMed 
    involved_in positive regulation of prostaglandin biosynthetic process  
    involved_in positive regulation of protein import into nucleus PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of smooth muscle contraction PubMed 
    involved_in positive regulation of synaptic plasticity PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
    involved_in positive regulation of transforming growth factor beta production PubMed 
    involved_in positive regulation of vascular endothelial growth factor production PubMed 
    involved_in positive regulation of vasoconstriction PubMed 
    involved_in prostaglandin biosynthetic process PubMed 
    involved_in prostaglandin biosynthetic process  
    acts_upstream_of_or_within prostaglandin secretion  
    acts_upstream_of_or_within regulation of blood pressure  
    involved_in regulation of blood pressure  
    acts_upstream_of_or_within regulation of cell population proliferation  
    involved_in regulation of neuroinflammatory response  
    involved_in regulation of neuroinflammatory response  
    involved_in response to angiotensin PubMed 
    involved_in response to cytokine PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to fatty acid PubMed 
    involved_in response to fructose PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to manganese ion PubMed 
    acts_upstream_of_or_within response to nematode  
    involved_in response to oxidative stress  
    involved_in response to selenium ion  
    acts_upstream_of_or_within response to selenium ion  
    involved_in response to tumor necrosis factor PubMed 
    involved_in response to vitamin D PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    Items 1 - 25 of 74
    Component Evidence Code Pubs
    located_in caveola PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in neuron projection  
    located_in neuron projection  
    located_in nuclear inner membrane  
    located_in nuclear inner membrane  
    located_in nuclear outer membrane  
    located_in nuclear outer membrane  
    NOT located_in nucleus  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    prostaglandin G/H synthase 2
    Names
    PGH synthase 2
    cyclooxygenase-2
    prostaglandin H2 synthase 2
    NP_058928.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017232.4NP_058928.3  prostaglandin G/H synthase 2 precursor

      See identical proteins and their annotated locations for NP_058928.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P35355, Q64379, Q925V4
      UniProtKB/TrEMBL
      A6ICR0, Q63124
      Related
      ENSRNOP00000003567.3, ENSRNOT00000003567.6
      Conserved Domains (2) summary
      cd09816
      Location:75562
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      pfam00008
      Location:2153
      EGF; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      64714063..64722320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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