Slc6a3 solute carrier family 6 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc6a3provided by RGD
Official Full Name: solute carrier family 6 member 3provided by RGD
Primary source: RGD:3715
See related: EnsemblRapid:ENSRNOG00000017302 AllianceGenome:RGD:3715
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dat1
Summary: Enables several functions, including amine binding activity; enzyme binding activity; and sodium:chloride symporter activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 15.2), Kidney (RPKM 0.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31537990..31578962, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29709443..29750413, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (32323011..32363983, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits.
Title: Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits.
Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure.
Title: Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure.
Inheritance of wild and truncated DAT alleles from grand-parents: Opposite transgenerational consequences on the behavioral phenotype in adolescent DAT heterozygous rats.
Title: Inheritance of wild and truncated DAT alleles from grand-parents: Opposite transgenerational consequences on the behavioral phenotype in adolescent DAT heterozygous rats.
Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.
Title: Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.
Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference.
Title: Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference.
Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior.
Title: Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior.
Effects of dopamine transporter changes in the ventral tegmental area of the midbrain on cognitive function in aged rats.
Title: Effects of dopamine transporter changes in the ventral tegmental area of the midbrain on cognitive function in aged rats.
[Influence of the DAT gene knockout on exchange of essential and toxic trace elements in rats].
Title: [Influence of the DAT gene knockout on exchange of essential and toxic trace elements in rats].
Own or dam's genotype? Classical colony breeding may bias spontaneous and stress-challenged activity in DAT-mutant rats.
Title: Own or dam's genotype? Classical colony breeding may bias spontaneous and stress-challenged activity in DAT-mutant rats.
Vapor Cannabis Exposure Promotes Genetic Plasticity in the Rat Hypothalamus.
Title: Vapor Cannabis Exposure Promotes Genetic Plasticity in the Rat Hypothalamus.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Rat377 (e-PCR), detects polymorphism
- UniSTS:227163

RH94400 (e-PCR)
- UniSTS:119648

PMC304098P2 (e-PCR)
- UniSTS:272521

RH94715 (e-PCR)
- UniSTS:119962

D1Wox51 (e-PCR)
- UniSTS:239558

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amine binding	IDA Inferred from Direct Assay more info	PubMed
enables amine binding	IPI Inferred from Physical Interaction more info	PubMed
enables dopamine binding	ISO Inferred from Sequence Orthology more info
enables dopamine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dopamine:sodium symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables dopamine:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables norepinephrine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenohypophysis development	ISO Inferred from Sequence Orthology more info
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in hyaloid vascular plexus regression	ISO Inferred from Sequence Orthology more info
involved_in hyaloid vascular plexus regression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine uptake	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prepulse inhibition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of flotillin complex	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sodium-dependent dopamine transporter

Names: DA transporter; DAT; solute carrier family 6 (neurotransmitter transporter), member 3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012694.2 → NP_036826.1 sodium-dependent dopamine transporter

See identical proteins and their annotated locations for NP_036826.1

Status: PROVISIONAL

Source sequence(s)

M80233

UniProtKB/Swiss-Prot

P23977

UniProtKB/TrEMBL

A6JUX6

Related

ENSRNOP00000047272.1, ENSRNOT00000040291.3

Conserved Domains (1) summary

cd11514
Location:60 → 613

SLC6sbd_DAT1; Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain