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    Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287005, updated on 9-Dec-2024

    Summary

    Official Symbol
    Camk2n1provided by RGD
    Official Full Name
    calcium/calmodulin-dependent protein kinase II inhibitor 1provided by RGD
    Primary source
    RGD:708430
    See related
    AllianceGenome:RGD:708430
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and positive regulation of systemic arterial blood pressure. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Orthologous to human CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1717.2), Kidney (RPKM 271.6) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Camk2n1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155958116..155959897)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150674819..150676600)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156876706..156878486)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 43, member B Neighboring gene mitochondrial E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC134479042 Neighboring gene ribosomal protein L12, pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in dendrite PubMed 
    located_in neuronal cell body PubMed 
    located_in postsynaptic density  
    located_in synapse  
    located_in synapse  

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase II inhibitor 1
    Names
    CaM-kinase II inhibitor alpha
    caM-KIINalpha
    caMKIINalpha
    calcium/calmodulin-dependent protein kinase II inhibitor alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173337.1NP_775459.1  calcium/calmodulin-dependent protein kinase II inhibitor 1

      See identical proteins and their annotated locations for NP_775459.1

      Status: PROVISIONAL

      Source sequence(s)
      AF271156
      UniProtKB/Swiss-Prot
      Q9JI15
      UniProtKB/TrEMBL
      A6ITI0
      Conserved Domains (1) summary
      pfam15170
      Location:178
      CaM-KIIN; Calcium/calmodulin-dependent protein kinase II inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      155958116..155959897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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