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    Oas1a 2'-5' oligoadenylate synthetase 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192281, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oas1aprovided by RGD
    Official Full Name
    2'-5' oligoadenylate synthetase 1Aprovided by RGD
    Primary source
    RGD:621760
    See related
    EnsemblRapid:ENSRNOG00000001369 AllianceGenome:RGD:621760
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oas1; Oas1g
    Summary
    Enables 2'-5'-oligoadenylate synthetase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of cytokine production; and regulation of innate immune response. Located in nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 97.7), Lung (RPKM 85.8) and 9 other tissues See more
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    Genomic context

    See Oas1a in Genome Data Viewer
    Location:
    12q16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41330423..41341130)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35669798..35680505)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41200680..41211393)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1D Neighboring gene uncharacterized LOC134481189 Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1H Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1F

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93097

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2'-5'-oligoadenylate synthetase activity  
    enables 2'-5'-oligoadenylate synthetase activity PubMed 
    enables 2'-5'-oligoadenylate synthetase activity  
    enables 2'-5'-oligoadenylate synthetase activity  
    enables ATP binding  
    enables double-stranded RNA binding  
    enables double-stranded RNA binding  
    enables double-stranded RNA binding  
    enables metal ion binding  
    enables nucleotidyltransferase activity  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in antiviral innate immune response  
    involved_in cellular response to interferon-alpha  
    involved_in cellular response to interferon-beta  
    involved_in defense response to virus  
    involved_in glucose homeostasis  
    involved_in glucose metabolic process  
    involved_in innate immune response  
    involved_in interleukin-27-mediated signaling pathway  
    involved_in interleukin-27-mediated signaling pathway  
    involved_in negative regulation of IP-10 production  
    involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production  
    involved_in negative regulation of type I interferon-mediated signaling pathway  
    involved_in negative regulation of viral genome replication  
    involved_in negative regulation of viral genome replication  
    involved_in positive regulation of cellular respiration  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of monocyte chemotactic protein-1 production  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in protein complex oligomerization  
    involved_in purine nucleotide biosynthetic process  
    involved_in regulation of ribonuclease activity  
    involved_in response to virus  
    involved_in response to virus PubMed 
    involved_in surfactant homeostasis  
    involved_in toll-like receptor 3 signaling pathway  
    involved_in toll-like receptor 4 signaling pathway  
    involved_in type I interferon-mediated signaling pathway  
    involved_in type I interferon-mediated signaling pathway  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    is_active_in membrane  
    located_in mitochondrion  
    located_in mitochondrion  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  
    located_in ribosome  

    General protein information

    Preferred Names
    2'-5'-oligoadenylate synthase 1A
    Names
    (2-5')oligo(A) synthase 1
    (2-5')oligo(A) synthase 1A
    (2-5')oligo(A) synthetase 1
    2',5'-oligoadenylate synthetase 1, 40/46kDa
    2'-5' oligoadenylate synthetase 1G
    2'-5'-oligoadenylate synthase 1
    2'-5'-oligoadenylate synthetase 1
    2-5A synthase 1
    2-5A synthase 1A
    2-5A synthetase 1
    25 oligoadenylate synthetase
    NP_620268.2
    XP_006249444.1
    XP_063127107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138913.2NP_620268.2  2'-5'-oligoadenylate synthase 1A

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q05961
      UniProtKB/TrEMBL
      A6J1H0, G3V9A4
      Related
      ENSRNOP00000048411.4, ENSRNOT00000041741.6
      Conserved Domains (2) summary
      cd05400
      Location:27167
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:165349
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41330423..41341130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249382.5XP_006249444.1  2'-5'-oligoadenylate synthase 1A isoform X1

      See identical proteins and their annotated locations for XP_006249444.1

      UniProtKB/Swiss-Prot
      Q05961
      UniProtKB/TrEMBL
      F7EEP6, Q5MYW5
      Related
      ENSRNOP00000040841.3, ENSRNOT00000048450.6
      Conserved Domains (2) summary
      cd05400
      Location:27167
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:164348
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    2. XM_063271037.1XP_063127107.1  2'-5'-oligoadenylate synthase 1A isoform X2

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