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    Supv3l1 Suv3 like RNA helicase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294385, updated on 9-Dec-2024

    Summary

    Official Symbol
    Supv3l1provided by RGD
    Official Full Name
    Suv3 like RNA helicaseprovided by RGD
    Primary source
    RGD:1305565
    See related
    EnsemblRapid:ENSRNOG00000000392 AllianceGenome:RGD:1305565
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable helicase activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial RNA 3'-end processing; mitochondrial RNA surveillance; and positive regulation of mitochondrial RNA catabolic process. Predicted to be located in mitochondrial nucleoid and nucleus. Predicted to be part of mitochondrial degradosome. Orthologous to human SUPV3L1 (Suv3 like RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 139.8), Kidney (RPKM 116.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Supv3l1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (30921248..30941779, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30378542..30399076, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32057530..32080170, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene hexokinase 1 Neighboring gene uncharacterized LOC134483920 Neighboring gene hexokinase domain containing 1 Neighboring gene U2 spliceosomal RNA Neighboring gene VPS26 retromer complex component A Neighboring gene uncharacterized LOC108353232 Neighboring gene serglycin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC109049

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity  
    enables 3'-5' RNA helicase activity  
    enables 3'-5' RNA helicase activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables DNA binding  
    enables DNA binding  
    enables DNA binding  
    enables DNA clamp loader activity  
    enables DNA helicase activity  
    enables DNA helicase activity  
    enables DNA helicase activity  
    enables RNA helicase activity  
    enables RNA helicase activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables double-stranded RNA binding  
    enables double-stranded RNA binding  
    enables double-stranded RNA binding  
    enables hydrolase activity, acting on acid anhydrides  
    enables identical protein binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 36
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in DNA duplex unwinding  
    involved_in DNA duplex unwinding  
    involved_in DNA recombination  
    involved_in DNA recombination  
    involved_in DNA recombination  
    involved_in RNA catabolic process  
    involved_in RNA catabolic process  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in mitochondrial RNA 3'-end processing  
    involved_in mitochondrial RNA 3'-end processing  
    involved_in mitochondrial RNA 3'-end processing  
    involved_in mitochondrial RNA 3'-end processing  
    involved_in mitochondrial RNA surveillance  
    involved_in mitochondrial RNA surveillance  
    involved_in mitochondrial mRNA catabolic process  
    involved_in mitochondrial mRNA catabolic process  
    involved_in mitochondrial mRNA surveillance  
    involved_in mitochondrial mRNA surveillance  
    involved_in mitochondrial mRNA surveillance  
    involved_in mitochondrial ncRNA surveillance  
    involved_in mitochondrial ncRNA surveillance  
    involved_in mitochondrial ncRNA surveillance  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of mitochondrial RNA catabolic process  
    involved_in positive regulation of mitochondrial RNA catabolic process  
    involved_in positive regulation of mitochondrial RNA catabolic process  
    Items 1 - 25 of 36
    Component Evidence Code Pubs
    part_of mitochondrial degradosome  
    part_of mitochondrial degradosome  
    part_of mitochondrial degradosome  
    part_of mitochondrial degradosome  
    located_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrial nucleoid  
    located_in mitochondrial nucleoid  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    ATP-dependent RNA helicase SUPV3L1, mitochondrial
    Names
    SUV3-like helicase
    SUV3-like protein 1
    suppressor of var1 3-like protein 1
    NP_001012480.1
    XP_038954515.1
    XP_038954516.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012462.1NP_001012480.1  ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001012480.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089883
      UniProtKB/Swiss-Prot
      Q5EBA1
      UniProtKB/TrEMBL
      A0A0G2K9R3
      Related
      ENSRNOP00000075096.3, ENSRNOT00000080773.3
      Conserved Domains (3) summary
      COG0513
      Location:208500
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:351486
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam12513
      Location:626672
      SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      30921248..30941779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098587.2XP_038954515.1  ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9R3
      Conserved Domains (5) summary
      cd18805
      Location:361499
      SF2_C_suv3; C-terminal helicase domain of ATP-dependent RNA helicase
      cd17913
      Location:200341
      DEXQc_Suv3; DEXQ-box helicase domain of Suv3
      pfam12513
      Location:638684
      SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal
      pfam18114
      Location:62179
      Suv3_N; Suv3 helical N-terminal domain
      pfam18147
      Location:570610
      Suv3_C_1; Suv3 C-terminal domain 1
    2. XM_039098588.2XP_038954516.1  ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform X2

      Conserved Domains (4) summary
      cd18805
      Location:84222
      SF2_C_suv3; C-terminal helicase domain of ATP-dependent RNA helicase
      pfam12513
      Location:361407
      SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal
      pfam18147
      Location:293333
      Suv3_C_1; Suv3 C-terminal domain 1
      cl28899
      Location:164
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RNA

    1. XR_005497211.2 RNA Sequence

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