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    Arhgef7 Rho guanine nucleotide exchange factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114559, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgef7provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 7provided by RGD
    Primary source
    RGD:620624
    See related
    EnsemblRapid:ENSRNOG00000012934 AllianceGenome:RGD:620624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P85spr; Pak3bp
    Summary
    Enables protein kinase binding activity. Contributes to small GTPase binding activity. Involved in actin cytoskeleton organization; astrocyte cell migration; and small GTPase-mediated signal transduction. Located in focal adhesion and growth cone. Part of protein-containing complex. Is active in GABA-ergic synapse. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 45.3), Lung (RPKM 43.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Arhgef7 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (84373123..84484759, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (77671021..77782593, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (83006732..83117065, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482535 Neighboring gene testis expressed 29 Neighboring gene uncharacterized LOC134482534 Neighboring gene uncharacterized LOC120097568 Neighboring gene ankyrin repeat domain 10 Neighboring gene inhibitor of growth family, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding  
    enables gamma-tubulin binding  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    contributes_to small GTPase binding PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization  
    involved_in Rho protein signal transduction  
    involved_in astrocyte cell migration PubMed 
    involved_in hematopoietic progenitor cell differentiation  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation  
    involved_in intracellular signal transduction  
    involved_in lamellipodium assembly  
    involved_in lamellipodium assembly  
    involved_in lamellipodium assembly  
    involved_in lamellipodium assembly  
    involved_in negative regulation of microtubule nucleation  
    involved_in negative regulation of microtubule nucleation  
    acts_upstream_of_or_within positive regulation of GTPase activity  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of growth hormone secretion  
    acts_upstream_of_or_within positive regulation of growth hormone secretion  
    involved_in positive regulation of lamellipodium morphogenesis PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading PubMed 
    involved_in postsynaptic actin cytoskeleton organization PubMed 
    involved_in postsynaptic actin cytoskeleton organization PubMed 
    involved_in presynaptic actin cytoskeleton organization PubMed 
    involved_in presynaptic actin cytoskeleton organization PubMed 
    involved_in small GTPase-mediated signal transduction PubMed 
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    located_in cell cortex  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in focal adhesion PubMed 
    located_in growth cone PubMed 
    is_active_in lamellipodium  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in mitotic spindle pole  
    located_in mitotic spindle pole  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    located_in postsynapse  
    located_in postsynapse  
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    located_in ruffle  
    located_in storage vacuole  
    located_in storage vacuole  
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 7
    Names
    PAK-interacting exchange factor beta
    Rho guanine nucleotide exchange factor (GEF) 7
    beta-Pix

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113521.3NP_001106993.3  rho guanine nucleotide exchange factor 7 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2QC21
      Related
      ENSRNOP00000095285.2, ENSRNOT00000100639.2
    2. NM_001113522.3NP_001106994.3  rho guanine nucleotide exchange factor 7 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2QC21
      Related
      ENSRNOP00000017947.6, ENSRNOT00000017947.6
    3. NM_053740.4NP_446192.4  rho guanine nucleotide exchange factor 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2QC21
      Related
      ENSRNOP00000103841.1, ENSRNOT00000171130.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      84373123..84484759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274984.1XP_063131054.1  rho guanine nucleotide exchange factor 7 isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q927
    2. XM_008771380.3XP_008769602.3  rho guanine nucleotide exchange factor 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP31
    3. XM_063274985.1XP_063131055.1  rho guanine nucleotide exchange factor 7 isoform X5

      UniProtKB/TrEMBL
      A0A8L2Q927
    4. XM_039094099.2XP_038950027.2  rho guanine nucleotide exchange factor 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AP31
    5. XM_039094100.2XP_038950028.2  rho guanine nucleotide exchange factor 7 isoform X7

      UniProtKB/TrEMBL
      A3KMH4, F1LNB0, Q52NK0
    6. XM_063274987.1XP_063131057.1  rho guanine nucleotide exchange factor 7 isoform X8

      UniProtKB/Swiss-Prot
      O55043
      UniProtKB/TrEMBL
      A6IWN1
    7. XM_008771376.4XP_008769598.3  rho guanine nucleotide exchange factor 7 isoform X4

      UniProtKB/TrEMBL
      A3KMH4
    8. XM_063274986.1XP_063131056.1  rho guanine nucleotide exchange factor 7 isoform X6

      UniProtKB/Swiss-Prot
      O55043
      UniProtKB/TrEMBL
      A6IWN1
      Related
      ENSRNOP00000043761.7, ENSRNOT00000043449.8
    9. XM_063274988.1XP_063131058.1  rho guanine nucleotide exchange factor 7 isoform X9

      UniProtKB/TrEMBL
      A3KMH4
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