U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Pla2g12a phospholipase A2, group XIIA [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362039, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pla2g12aprovided by RGD
    Official Full Name
    phospholipase A2, group XIIAprovided by RGD
    Primary source
    RGD:1304662
    See related
    EnsemblRapid:ENSRNOG00000057470 AllianceGenome:RGD:1304662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipase A2 activity. Predicted to be involved in arachidonate secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region. Orthologous to human PLA2G12A (phospholipase A2 group XIIA). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 333.5), Kidney (RPKM 93.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pla2g12a in Genome Data Viewer
    Location:
    2q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (221110722..221126966)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (218436497..218452742)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (235311664..235327972)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485966 Neighboring gene complement factor I Neighboring gene uncharacterized LOC120100942 Neighboring gene uncharacterized LOC134485965 Neighboring gene caspase 6 Neighboring gene mitochondrial calcium uniporter dominant negative subunit beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables phospholipase A2 activity  
    enables phospholipase A2 activity  
    Process Evidence Code Pubs
    involved_in arachidonate secretion  
    involved_in lipid catabolic process  
    involved_in phospholipid metabolic process  
    Component Evidence Code Pubs
    located_in extracellular region  

    General protein information

    Preferred Names
    group XIIA secretory phospholipase A2
    NP_001382508.1
    NP_001382509.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395579.1NP_001382508.1  group XIIA secretory phospholipase A2 precursor

      Status: VALIDATED

      Source sequence(s)
      FM046181, FM059472, JAXUCZ010000002
      UniProtKB/TrEMBL
      B0K018
      Related
      ENSRNOP00000073613.2, ENSRNOT00000087287.3
      Conserved Domains (1) summary
      pfam06951
      Location:27192
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
    2. NM_001395580.1NP_001382509.1  group XIIA secretory phospholipase A2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      B0K018
      Related
      ENSRNOP00000101220.1, ENSRNOT00000139510.1
      Conserved Domains (1) summary
      pfam06951
      Location:27192
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      221110722..221126966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    External link. Please review our privacy policy.