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    Arhgef10 Rho guanine nucleotide exchange factor 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306618, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef10provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 10provided by RGD
    Primary source
    RGD:1565043
    See related
    EnsemblRapid:ENSRNOG00000012561 AllianceGenome:RGD:1565043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565043
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and kinesin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be active in centrosome and cytoplasm. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 104.2), Heart (RPKM 72.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef10 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (81349429..81440439, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (74647147..74738784, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (79725629..79817065, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551089 Neighboring gene myomesin 2 Neighboring gene uncharacterized LOC102551149 Neighboring gene kelch repeat and BTB domain containing 11 Neighboring gene uncharacterized LOC134482526 Neighboring gene uncharacterized LOC102557538 Neighboring gene uncharacterized LOC134482525 Neighboring gene uncharacterized LOC134482527 Neighboring gene CLN8, transmembrane ER and ERGIC protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke. Matsushita T, et al. Hum Mol Genet, 2010 Mar 15. PMID 20042462
    2. Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture. Mohl M, et al. Naunyn Schmiedebergs Arch Pharmacol, 2006 Aug. PMID 16896804
    3. Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. Aoki T, et al. BMC Cell Biol, 2009 Jul 28. PMID 19635168, Free PMC Article
    4. Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10. Verhoeven K, et al. Am J Hum Genet, 2003 Oct. PMID 14508709, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 10
    Names
    Rho guanine nucleotide exchange factor (GEF) 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427033.1 → NP_001413962.1  rho guanine nucleotide exchange factor 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IWD5, M0R3X3
      Related
      ENSRNOP00000064046.3, ENSRNOT00000073971.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      81349429..81440439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275478.1 → XP_063131548.1  rho guanine nucleotide exchange factor 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0S7, A6IWD5

    2. XM_006253400.5 → XP_006253462.1  rho guanine nucleotide exchange factor 10 isoform X1

      See identical proteins and their annotated locations for XP_006253462.1

      UniProtKB/TrEMBL
      A6IWD5, M0R3X3
      Conserved Domains (2) summary
      pfam00621
      Location:436 → 614
      RhoGEF; RhoGEF domain
      cl17171
      Location:646 → 712
      PH-like; Pleckstrin homology-like domain

    3. XM_006253403.5 → XP_006253465.1  rho guanine nucleotide exchange factor 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0S7, A6IWD5
      Related
      ENSRNOP00000085722.1, ENSRNOT00000119970.2
      Conserved Domains (2) summary
      pfam00621
      Location:400 → 578
      RhoGEF; RhoGEF domain
      cl17171
      Location:610 → 676
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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