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    Lonp1 lon peptidase 1, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170916, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lonp1provided by RGD
    Official Full Name
    lon peptidase 1, mitochondrialprovided by RGD
    Primary source
    RGD:621598
    See related
    EnsemblRapid:ENSRNOG00000046502 AllianceGenome:RGD:621598
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lon; Prss15
    Summary
    Enables ATP-dependent peptidase activity. Involved in several processes, including mitochondrion organization; response to aluminum ion; and response to hypoxia. Located in mitochondrial matrix. Used to study brain ischemia and ischemia. Human ortholog(s) of this gene implicated in CODAS syndrome. Orthologous to human LONP1 (lon peptidase 1, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 987.4), Kidney (RPKM 361.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lonp1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1534581..1546908, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1447444..1459771, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10428853..10441180)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene mitochondrial contact site and cristae organizing system subunit 13 Neighboring gene ribosomal protein L36 Neighboring gene cation channel sperm associated auxiliary subunit delta Neighboring gene RAN binding protein 3 Neighboring gene calcyphosine Neighboring gene vimentin-type intermediate filament associated coiled-coil protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding  
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent peptidase activity  
    enables ATP-dependent peptidase activity PubMed 
    enables ATP-dependent peptidase activity  
    enables ATP-dependent peptidase activity  
    enables DNA polymerase binding  
    enables G-quadruplex DNA binding  
    enables PH domain binding  
    enables identical protein binding  
    enables insulin receptor substrate binding  
    NOT enables mitochondrial promoter sequence-specific DNA binding  
    enables mitochondrial promoter sequence-specific DNA binding  
    enables sequence-specific DNA binding  
    enables sequence-specific DNA binding  
    enables serine-type endopeptidase activity  
    enables single-stranded DNA binding  
    enables single-stranded DNA binding  
    enables single-stranded RNA binding  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress  
    involved_in cellular response to oxidative stress  
    involved_in chaperone-mediated protein complex assembly  
    involved_in chaperone-mediated protein complex assembly  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization PubMed 
    involved_in mitochondrion organization  
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway  
    involved_in oxidation-dependent protein catabolic process  
    involved_in oxidation-dependent protein catabolic process  
    involved_in protein catabolic process PubMed 
    involved_in protein catabolic process  
    involved_in protein quality control for misfolded or incompletely synthesized proteins  
    involved_in protein quality control for misfolded or incompletely synthesized proteins  
    involved_in protein-containing complex assembly PubMed 
    acts_upstream_of_or_within proteolysis  
    involved_in proteolysis involved in protein catabolic process  
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation  
    involved_in response to aluminum ion PubMed 
    involved_in response to hormone PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to hypoxia  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix PubMed 
    located_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrial nucleoid  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    lon protease homolog, mitochondrial
    Names
    LONP
    lon protease-like protein
    mitochondrial ATP-dependent protease Lon
    protease, serine, 15
    serine protease 15
    NP_596895.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133404.1NP_596895.1  lon protease homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_596895.1

      Status: PROVISIONAL

      Source sequence(s)
      AB064323
      UniProtKB/Swiss-Prot
      Q924S5
      UniProtKB/TrEMBL
      A0A8I6AS66, A6KQW3
      Related
      ENSRNOP00000066618.2, ENSRNOT00000074253.3
      Conserved Domains (5) summary
      smart00464
      Location:111188
      LON; Found in ATP-dependent protease La (LON)
      TIGR00763
      Location:113937
      lon; endopeptidase La
      pfam00004
      Location:509651
      AAA; ATPase family associated with various cellular activities (AAA)
      cl21455
      Location:479530
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl21678
      Location:727938
      ChlI; Subunit ChlI of Mg-chelatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1534581..1546908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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