Hyls1 HYLS1, centriolar and ciliogenesis associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hyls1provided by RGD
Official Full Name: HYLS1, centriolar and ciliogenesis associatedprovided by RGD
Primary source: RGD:1594169
See related: EnsemblRapid:ENSRNOG00000012980 AllianceGenome:RGD:1594169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in cilium assembly. Predicted to be located in several cellular components, including centrosome; cytosol; and nucleus. Predicted to be active in centriole and non-motile cilium. Human ortholog(s) of this gene implicated in hydrolethalus syndrome 1. Orthologous to human HYLS1 (HYLS1 centriolar and ciliogenesis associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 109.2), Thymus (RPKM 65.7) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (42170505..42179573, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (33912692..33921760, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (36763470..36772199, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

BF389095 (e-PCR)
- UniSTS:245368

Hyls1 (e-PCR), detects polymorphism
- UniSTS:528054

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: centriolar and ciliogenesis-associated protein HYLS1

Names: hydrolethalus syndrome 1; hydrolethalus syndrome protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398961.1 → NP_001385890.1 centriolar and ciliogenesis-associated protein HYLS1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6JYK9, F1M147

Conserved Domains (1) summary

pfam15311
Location:212 → 298

HYLS1_C; Hydrolethalus syndrome protein 1 C-terminus
NM_001398962.1 → NP_001385891.1 centriolar and ciliogenesis-associated protein HYLS1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6JYK9, F1M147

Related

ENSRNOP00000098711.1, ENSRNOT00000164399.1

Conserved Domains (1) summary

pfam15311
Location:212 → 298

HYLS1_C; Hydrolethalus syndrome protein 1 C-terminus