Qrsl1 glutaminyl-tRNA amidotransferase subunit QRSL1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Qrsl1provided by RGD
Official Full Name: glutaminyl-tRNA amidotransferase subunit QRSL1provided by RGD
Primary source: RGD:1359490
See related: EnsemblRapid:ENSRNOG00000026049 AllianceGenome:RGD:1359490
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to act upstream of or within regulation of protein stability. Predicted to be part of glutamyl-tRNA(Gln) amidotransferase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 113.9), Muscle (RPKM 69.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (48939858..48964812, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (47357206..47382160, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (48855839..48881112, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH129971 (e-PCR)
- UniSTS:213259

RH133719 (e-PCR)
- UniSTS:217002

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
contributes_to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	IEA Inferred from Electronic Annotation more info
involved_in glutaminyl-tRNAGln biosynthesis via transamidation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of glutamyl-tRNA(Gln) amidotransferase complex	IEA Inferred from Electronic Annotation more info
part_of glutamyl-tRNA(Gln) amidotransferase complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Names: QRSL1, glutaminyl-tRNA amidotransferase subunit A; glu-AdT subunit A; glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1; glutaminyl-tRNA synthase-like protein 1; glutamyl-tRNA(Gln) amidotransferase subunit A homolog

NP_001014056.1

EC 6.3.5.7

XP_063135257.1

EC 6.3.5.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014034.2 → NP_001014056.1 glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

See identical proteins and their annotated locations for NP_001014056.1

Status: VALIDATED

Source sequence(s)

BC089213, JAXUCZ010000020

UniProtKB/Swiss-Prot

Q5FWT5

UniProtKB/TrEMBL

A0A8I5ZPV2

Related

ENSRNOP00000018891.5, ENSRNOT00000018892.9

Conserved Domains (2) summary

PRK00012
Location:13 → 492

gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed

PRK07488
Location:5 → 493

PRK07488; indole acetimide hydrolase; Validated