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    Mtbp MDM2 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500870, updated on 9-Dec-2024

    Summary

    Symbol
    Mtbpprovided by RGD
    Full Name
    MDM2 binding proteinprovided by RGD
    Primary source
    RGD:1565672
    See related
    EnsemblRapid:ENSRNOG00000004412 AllianceGenome:RGD:1565672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565672
    Summary
    Predicted to be involved in protein localization to kinetochore and traversing start control point of mitotic cell cycle. Predicted to act upstream of or within negative regulation of cell population proliferation and negative regulation of mitotic nuclear division. Predicted to be located in chromatin. Predicted to be active in kinetochore. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 40.4), Thymus (RPKM 33.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mtbp in Genome Data Viewer
    Location:
    7q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (88862939..88945491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86973215..87055775)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (95309928..95392418)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene collagen type XIV alpha 1 chain Neighboring gene eukaryotic translation initiation factor 1, pseudogene 1 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene uncharacterized LOC120093658 Neighboring gene syntrophin, beta 1 Neighboring gene transfer RNA lysine (anticodon CUU) 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in kinetochore  
    located_in kinetochore  

    General protein information

    Preferred Names
    mdm2-binding protein
    Names
    Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130717.2NP_001124189.2  mdm2-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HRH7, D4AB60
      Related
      ENSRNOP00000005887.5, ENSRNOT00000005887.6
      Conserved Domains (3) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294633
      MTBP_mid; MDM2-binding
      pfam14920
      Location:637891
      MTBP_C; MDM2-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      88862939..88945491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241656.5XP_006241718.1  mdm2-binding protein isoform X2

      See identical proteins and their annotated locations for XP_006241718.1

      UniProtKB/TrEMBL
      A6HRH7, D4AB60
      Related
      ENSRNOP00000100117.1, ENSRNOT00000141688.1
      Conserved Domains (3) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294633
      MTBP_mid; MDM2-binding
      pfam14920
      Location:637867
      MTBP_C; MDM2-binding
    2. XM_039079751.2XP_038935679.1  mdm2-binding protein isoform X3

      UniProtKB/TrEMBL
      A6HRH7, D4AB60
      Conserved Domains (3) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294633
      MTBP_mid; MDM2-binding
      pfam14920
      Location:637802
      MTBP_C; MDM2-binding
    3. XM_063264120.1XP_063120190.1  mdm2-binding protein isoform X1

      UniProtKB/TrEMBL
      A6HRH7, D4AB60
    4. XM_039079754.2XP_038935682.2  mdm2-binding protein isoform X4

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