U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Rab8b RAB8B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266688, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab8bprovided by RGD
    Official Full Name
    RAB8B, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:628764
    See related
    AllianceGenome:RGD:628764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables TPR domain binding activity. Involved in cell-substrate junction organization; positive regulation of cell projection organization; and positive regulation of corticotropin secretion. Located in cell tip and perinuclear region of cytoplasm. Is active in presynapse. Orthologous to human RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 183.9), Thymus (RPKM 108.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rab8b in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76340106..76417638, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67458921..67536466, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72641680..72714646, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene aph-1 homolog B, gamma secretase subunit like 1 Neighboring gene aph-1 homolog B, gamma secretase subunit Neighboring gene small nucleolar RNA SNORA8 Neighboring gene cytochrome c oxidase subunit 6A1, pseudogene 1 Neighboring gene uncharacterized LOC102554897

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTPase activity  
    enables TPR domain binding PubMed 
    enables protein binding PubMed 
    enables signaling receptor binding  
    Component Evidence Code Pubs
    located_in cell tip PubMed 
    is_active_in endosome  
    located_in endosome membrane  
    located_in endosome membrane  
    located_in perinuclear region of cytoplasm PubMed 
    located_in peroxisomal membrane  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle membrane  
    is_active_in plasma membrane  
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 
    is_active_in synaptic vesicle  
    is_active_in trans-Golgi network transport vesicle  

    General protein information

    Preferred Names
    ras-related protein Rab-8B
    Names
    GTPase Rab8b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153317.3NP_695229.1  ras-related protein Rab-8B

      See identical proteins and their annotated locations for NP_695229.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P70550
      UniProtKB/TrEMBL
      B0BMV5
      Conserved Domains (1) summary
      cd01867
      Location:6172
      Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      76340106..76417638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080935.2XP_038936863.1  ras-related protein Rab-8B isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:191
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_039080932.2XP_038936860.1  ras-related protein Rab-8B isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:682
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    External link. Please review our privacy policy.