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    Sptssb serine palmitoyltransferase, small subunit B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362555, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sptssbprovided by RGD
    Official Full Name
    serine palmitoyltransferase, small subunit Bprovided by RGD
    Primary source
    RGD:2324614
    See related
    EnsemblRapid:ENSRNOG00000009388 AllianceGenome:RGD:2324614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to contribute to serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process; endoplasmic reticulum organization; and sphingosine biosynthetic process. Predicted to act upstream of or within regulation of serine C-palmitoyltransferase activity and sphingolipid biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Orthologous to human SPTSSB (serine palmitoyltransferase small subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 37.3), Brain (RPKM 34.8) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Sptssb in Genome Data Viewer
    Location:
    2q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (156432509..156461936, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (154133728..154162127, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (166654036..166682325, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NMD3 ribosome export adaptor Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 13 Neighboring gene otolin 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of serine palmitoyltransferase complex  

    General protein information

    Preferred Names
    serine palmitoyltransferase small subunit B
    Names
    androgen down regulated in mouse prostate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271299.1 → NP_001258228.1  serine palmitoyltransferase small subunit B

      See identical proteins and their annotated locations for NP_001258228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC087706, FM125939
      UniProtKB/TrEMBL
      A6J5N9
      Related
      ENSRNOP00000100272.1, ENSRNOT00000091198.3
      Conserved Domains (1) summary
      pfam11779
      Location:7 → 60
      SPT_ssu-like; Small subunit of serine palmitoyltransferase-like
    2. NM_001271301.1 → NP_001258230.1  serine palmitoyltransferase small subunit B

      See identical proteins and their annotated locations for NP_001258230.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC087706
      UniProtKB/TrEMBL
      A6J5N9
      Related
      ENSRNOP00000109949.1, ENSRNOT00000012422.7
      Conserved Domains (1) summary
      pfam11779
      Location:7 → 60
      SPT_ssu-like; Small subunit of serine palmitoyltransferase-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      156432509..156461936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281087.1 → XP_063137157.1  serine palmitoyltransferase small subunit B isoform X1

      UniProtKB/TrEMBL
      A6J5N9
    2. XM_063281086.1 → XP_063137156.1  serine palmitoyltransferase small subunit B isoform X1

      UniProtKB/TrEMBL
      A6J5N9
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