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    Araf A-Raf proto-oncogene, serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64363, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arafprovided by RGD
    Official Full Name
    A-Raf proto-oncogene, serine/threonine kinaseprovided by RGD
    Primary source
    RGD:2148
    See related
    EnsemblRapid:ENSRNOG00000010838 AllianceGenome:RGD:2148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Araf1
    Summary
    Enables MAP kinase kinase kinase activity. Involved in protein phosphorylation. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 202.0), Heart (RPKM 181.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Araf in Genome Data Viewer
    Location:
    Xq11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (3780932..3845919, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1227392..1292356, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1369534..1391603, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene synapsin I Neighboring gene 60S ribosomal protein L12-like Neighboring gene TIMP metallopeptidase inhibitor 1 Neighboring gene uncharacterized LOC134484040 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ribosomal protein L22 like 1, pseudogene 1 Neighboring gene prothymosin alpha like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf. Ishikawa F, et al. Oncogene Res, 1987 Aug. PMID 3449797
    2. IGFBP2 expression predicts IDH-mutant glioma patient survival. Huang LE, et al. Oncotarget, 2017 Jan 3. PMID 27852048, Free PMC Article
    3. Characterization of murine A-raf, a new oncogene related to the v-raf oncogene. Huleihel M, et al. Mol Cell Biol, 1986 Jul. PMID 3491291, Free PMC Article
    4. DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. Yokoyama T, et al. J Cell Biol, 2007 Jun 4. PMID 17535970, Free PMC Article
    5. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA, et al. FEBS Lett, 2000 Jan 21. PMID 10648842

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase kinase kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase A-Raf
    Names
    A-Raf proto-oncogene serine/threonine-protein kinase
    Raf related protein
    Ras-binding protein
    proto-oncogene A-Raf
    proto-oncogene A-Raf-1
    v-raf murine sarcoma 3611 viral oncogene homolog 1
    v-raf oncogene homolog 1 (murine sarcoma 3611 virus)
    NP_001028835.1
    NP_071977.1
    XP_038955949.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033663.2 → NP_001028835.1  serine/threonine-protein kinase A-Raf isoform 2

      See identical proteins and their annotated locations for NP_001028835.1

      Status: VALIDATED

      Source sequence(s)
      AB158253, AI060060, CO572305, DV728203
      UniProtKB/TrEMBL
      A0A8I5ZXA9, A6JZR7, A6JZR9, A6JZS1, Q6P9W2
      Conserved Domains (2) summary
      cd01816
      Location:20 → 91
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00130
      Location:99 → 146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. NM_022532.2 → NP_071977.1  serine/threonine-protein kinase A-Raf isoform 1

      See identical proteins and their annotated locations for NP_071977.1

      Status: VALIDATED

      Source sequence(s)
      AI712552, CO572305, X06942
      UniProtKB/Swiss-Prot
      P14056
      UniProtKB/TrEMBL
      A6JZR3, A6JZR6
      Related
      ENSRNOP00000048890.6, ENSRNOT00000039911.5
      Conserved Domains (4) summary
      cd01816
      Location:20 → 91
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00069
      Location:309 → 563
      Pkinase; Protein kinase domain
      pfam00130
      Location:99 → 146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:307 → 571
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      3780932..3845919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100021.2 → XP_038955949.1  serine/threonine-protein kinase A-Raf isoform X1

      UniProtKB/TrEMBL
      A6JZR2, A6JZR3
      Conserved Domains (3) summary
      cd17133
      Location:56 → 128
      RBD_ARAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase ARAF
      cd20870
      Location:133 → 184
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
      cl21453
      Location:344 → 608
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14056.1 GenPept UniProtKB/Swiss-Prot:P14056

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