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    Tax1bp3 Tax1 binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360564, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tax1bp3provided by RGD
    Official Full Name
    Tax1 binding protein 3provided by RGD
    Primary source
    RGD:1308924
    See related
    EnsemblRapid:ENSRNOG00000019357 AllianceGenome:RGD:1308924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; activation of GTPase activity; and negative regulation of protein localization to cell surface. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in actin cytoskeleton; cytoplasm; and fibrillar center. Predicted to be active in nucleus. Orthologous to human TAX1BP3 (Tax1 binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 341.3), Lung (RPKM 321.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tax1bp3 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58294357..58298875)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57795845..57800363)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59743356..59748063)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 5 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene cystinosin, lysosomal cystine transporter Neighboring gene sedoheptulokinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    located_in actin cytoskeleton  
    located_in cytoplasm  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in intracellular membrane-bounded organelle  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    tax1-binding protein 3
    Names
    Tax1 (human T-cell leukemia virus type I) binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025419.2NP_001020590.1  tax1-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001020590.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q4QQV1
      Related
      ENSRNOP00000076077.3, ENSRNOT00000093497.3
    2. NM_001399570.1NP_001386499.1  tax1-binding protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8L2QRP0, A6HGI4
      Related
      ENSRNOP00000103419.1, ENSRNOT00000127012.1
      Conserved Domains (1) summary
      cd00992
      Location:13109
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      58294357..58298875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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