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    Flnb filamin B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306204, updated on 9-Dec-2024

    Summary

    Symbol
    Flnbprovided by RGD
    Full Name
    filamin Bprovided by RGD
    Primary source
    RGD:1311915
    See related
    EnsemblRapid:ENSRNOG00000009470 AllianceGenome:RGD:1311915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within several processes, including cellular response to type II interferon; epithelial cell development; and skeletal muscle tissue development. Located in neuronal cell body. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 310.7), Lung (RPKM 189.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Flnb in Genome Data Viewer
    Location:
    15p14
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19392212..19525278, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16961999..17095059, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18750152..18883019, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 1L3 Neighboring gene uncharacterized LOC103693818 Neighboring gene ATP6V1F neighbor like Neighboring gene uncharacterized LOC134482086 Neighboring gene ribosomal protein S19, pseudogene 15 Neighboring gene POTE ankyrin domain family member H Neighboring gene UTP4 small subunit processome component, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding  
    enables identical protein binding  
    Component Evidence Code Pubs
    located_in brush border  
    located_in cytosol  
    located_in focal adhesion  
    located_in neuronal cell body PubMed 
    located_in phagocytic vesicle  
    located_in plasma membrane  
    located_in stress fiber  

    General protein information

    Preferred Names
    filamin-B
    Names
    filamin B, beta
    filamin, beta
    filamin-B-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107288.2NP_001100758.1  filamin-B isoform 3

      See identical proteins and their annotated locations for NP_001100758.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6GK95, A6K0C4, D4A8D5
      Related
      ENSRNOP00000061198.1, ENSRNOT00000066546.3
      Conserved Domains (3) summary
      smart00557
      Location:14211514
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:17121
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00630
      Location:14181508
      Filamin; Filamin/ABP280 repeat
    2. NM_001431546.1NP_001418475.1  filamin-B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2JXT8, A0A8I6GK95
    3. NM_001431547.1NP_001418476.1  filamin-B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6GK95

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      19392212..19525278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251780.5XP_006251842.1  filamin-B isoform X1

      Related
      ENSRNOP00000070399.1, ENSRNOT00000088264.3
      Conserved Domains (3) summary
      smart00557
      Location:14211514
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:17121
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00630
      Location:14181508
      Filamin; Filamin/ABP280 repeat
    2. XM_006251781.5XP_006251843.1  filamin-B isoform X2

      Conserved Domains (3) summary
      smart00557
      Location:14211514
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:17121
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00630
      Location:14181508
      Filamin; Filamin/ABP280 repeat
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