Fgfrl1 fibroblast growth factor receptor-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgfrl1provided by RGD
Official Full Name: fibroblast growth factor receptor-like 1provided by RGD
Primary source: RGD:735156
See related: EnsemblRapid:ENSRNOG00000024207 AllianceGenome:RGD:735156
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fgfr5
Summary: Predicted to enable several functions, including fibroblast growth factor binding activity; fibroblast growth factor receptor activity; and heparin binding activity. Predicted to be involved in cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to act upstream of or within several processes, including diaphragm development; heart development; and skeletal system development. Predicted to be located in Golgi apparatus; cell-cell contact zone; and transport vesicle. Predicted to be active in plasma membrane. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 54.8), Kidney (RPKM 52.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (1154275..1166334, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (1009863..1022620, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (2020110..2032169, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

downregulation of the FGFRL1 gene during the late stages of gestation may contribute to the development of the diaphragmatic defect in nitrofen-induced CDH
Title: Downregulation of FGFRL1 contributes to the development of the diaphragmatic defect in the nitrofen model of congenital diaphragmatic hernia.
EGFR, FGFR and TNFR1 mRNA expression was equal or lower than in resting liver, HGFR expression after I/R was stronger than in the control.
Title: Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors.
Analysis of Fgf18 and Fgfr5 (Fgfrl1) expression in primary endothelial cells and vascular smooth muscle cells.
Title: Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells.

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General gene information

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Markers

Fgfrl1 (e-PCR), detects polymorphism
- UniSTS:515314

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in diaphragm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within diaphragm development	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in heart valve morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell-cell contact zone	IEA Inferred from Electronic Annotation more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor receptor-like 1

Names: FGF receptor-like protein 1; alpha-L-iduronidase; fibroblast growth factor receptor 5; fibroblast growth factor receptor-like protein

NP_954545.1

EC 3.2.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199114.1 → NP_954545.1 fibroblast growth factor receptor-like 1 precursor

See identical proteins and their annotated locations for NP_954545.1

Status: PROVISIONAL

Source sequence(s)

AJ536020

UniProtKB/Swiss-Prot

Q4V8P8, Q7TQM3

UniProtKB/TrEMBL

A0A8I6ASQ6

Related

ENSRNOP00000097460.2, ENSRNOT00000108147.2

Conserved Domains (4) summary

pfam07679
Location:29 → 112

I-set; Immunoglobulin I-set domain

cd00096
Location:242 → 245

Ig; Ig strand A [structural motif]

cd05856
Location:143 → 234

IgI_2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains

cl11960
Location:242 → 350

Ig; Immunoglobulin domain