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    Chst5 carbohydrate sulfotransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307859, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chst5provided by RGD
    Official Full Name
    carbohydrate sulfotransferase 5provided by RGD
    Primary source
    RGD:1561144
    See related
    EnsemblRapid:ENSRNOG00000021521 AllianceGenome:RGD:1561144
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561144
    Summary
    Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity and keratan sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process and keratan sulfate biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Human ortholog(s) of this gene implicated in macular corneal dystrophy. Orthologous to several human genes including CHST6 (carbohydrate sulfotransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 9.4), Brain (RPKM 9.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chst5 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56769991..56790276, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39860729..39881019, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (44115065..44136092, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 170A Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 231 Neighboring gene GABA type A receptor associated protein like 2 Neighboring gene adenosine deaminase, tRNA-specific 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). Bartes A, et al. Biochem Biophys Res Commun, 2001 Apr 13. PMID 11352640
    2. Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate. Akama TO, et al. J Biol Chem, 2001 May 11. PMID 11278593
    3. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. Akama TO, et al. J Biol Chem, 2002 Nov 8. PMID 12218059
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine 6-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables keratan sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratan sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 5
    Names
    carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
    NP_001100901.1
    XP_006255694.1
    XP_006255695.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107431.1 → NP_001100901.1  carbohydrate sulfotransferase 5

      See identical proteins and their annotated locations for NP_001100901.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IZB3, D4A9P8
      Related
      ENSRNOP00000026262.2, ENSRNOT00000026262.7
      Conserved Domains (1) summary
      cl21551
      Location:190 → 380
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56769991..56790276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255633.5 → XP_006255695.1  carbohydrate sulfotransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_006255695.1

      UniProtKB/TrEMBL
      A0A8I6GGK1, A6IZB4
      Related
      ENSRNOP00000088767.1, ENSRNOT00000109790.2
      Conserved Domains (1) summary
      pfam13469
      Location:43 → 297
      Sulfotransfer_3; Sulfotransferase family

    2. XM_006255632.5 → XP_006255694.1  carbohydrate sulfotransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_006255694.1

      UniProtKB/TrEMBL
      A0A8I6GGK1, A6IZB4
      Conserved Domains (1) summary
      pfam13469
      Location:43 → 297
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version

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