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    Dph7 diphthamide biosynthesis 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296550, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dph7provided by RGD
    Official Full Name
    diphthamide biosynthesis 7provided by RGD
    Primary source
    RGD:1304868
    See related
    EnsemblRapid:ENSRNOG00000008102 AllianceGenome:RGD:1304868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304868
    Summary
    Predicted to enable diphthine methylesterase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be active in cytoplasm. Orthologous to human DPH7 (diphthamide biosynthesis 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 85.6), Brain (RPKM 63.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dph7 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28168466..28177173)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7770368..7778994)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2170193..2179101)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486057 Neighboring gene arrestin domain containing 1 Neighboring gene zinc finger, MYND-type containing 19 Neighboring gene mitochondrial ribosomal protein L41 Neighboring gene patatin-like phospholipase domain containing 7 Neighboring gene glutathione S-transferase pi 1, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Haploid genetic screens in human cells identify host factors used by pathogens. Carette JE, et al. Science, 2009 Nov 27. PMID 19965467
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables diphthine methylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein histidyl modification to diphthamide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein histidyl modification to diphthamide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diphthine methyltransferase
    NP_001381269.1
    NP_001381270.1
    XP_063139524.1
    XP_063139525.1
    XP_063139526.1
    XP_063139527.1
    XP_063139528.1
    XP_063139529.1
    XP_063139530.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394340.1 → NP_001381269.1  diphthine methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4A1S8
      Related
      ENSRNOP00000040931.5, ENSRNOT00000046898.6
      Conserved Domains (2) summary
      COG2319
      Location:66 → 322
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:90 → 137
      7WD40; WD40 repeat [structural motif]

    2. NM_001394341.1 → NP_001381270.1  diphthine methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JSZ7
      Conserved Domains (2) summary
      COG2319
      Location:2 → 97
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:16 → 52
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_172099.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28168466..28177173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283454.1 → XP_063139524.1  diphthine methyltransferase isoform X1

    2. XM_063283455.1 → XP_063139525.1  diphthine methyltransferase isoform X2

    3. XM_063283456.1 → XP_063139526.1  diphthine methyltransferase isoform X3

    4. XM_063283457.1 → XP_063139527.1  diphthine methyltransferase isoform X3

    5. XM_063283459.1 → XP_063139529.1  diphthine methyltransferase isoform X4

      UniProtKB/TrEMBL
      A6JSZ7

    6. XM_063283458.1 → XP_063139528.1  diphthine methyltransferase isoform X4

      UniProtKB/TrEMBL
      A6JSZ7

    7. XM_063283460.1 → XP_063139530.1  diphthine methyltransferase isoform X4

      UniProtKB/TrEMBL
      A6JSZ7

    RNA

    1. XR_010064600.1 RNA Sequence

    2. XR_010064601.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials