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    Calr calreticulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64202, updated on 9-Dec-2024

    Summary

    Official Symbol
    Calrprovided by RGD
    Official Full Name
    calreticulinprovided by RGD
    Primary source
    RGD:620288
    See related
    EnsemblRapid:ENSRNOG00000003029 AllianceGenome:RGD:620288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including hormone binding activity; metal ion binding activity; and peptide binding activity. Involved in several processes, including cellular response to electrical stimulus; cellular response to lithium ion; and response to testosterone. Located in several cellular components, including acrosomal vesicle; endoplasmic reticulum; and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in endoplasmic reticulum; glutamatergic synapse; and postsynapse. Biomarker of vitamin B12 deficiency. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 2967.5), Kidney (RPKM 2083.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Calr in Genome Data Viewer
    Location:
    19q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40213367..40218262)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23308525..23313420)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25956771..25961666, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene synaptonemal complex central element protein 2 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene GADD45G interacting protein 1 Neighboring gene DAN domain BMP antagonist family member 5 Neighboring gene uncharacterized LOC134483324

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables calcium ion binding  
    enables calcium ion binding  
    enables carbohydrate binding  
    enables carbohydrate binding  
    enables complement component C1q complex binding  
    enables hormone binding PubMed 
    enables integrin binding  
    enables iron ion binding PubMed 
    enables mRNA binding PubMed 
    enables mRNA binding  
    enables molecular sequestering activity  
    enables nuclear androgen receptor binding  
    enables nuclear export signal receptor activity  
    enables peptide binding PubMed 
    enables protein binding PubMed 
    enables ubiquitin protein ligase binding  
    enables unfolded protein binding  
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in ERAD pathway  
    involved_in cardiac muscle cell differentiation PubMed 
    involved_in cellular response to electrical stimulus PubMed 
    involved_in cellular response to lithium ion PubMed 
    involved_in cellular response to virus PubMed 
    involved_in cellular senescence  
    acts_upstream_of_or_within cortical actin cytoskeleton organization  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of intracellular steroid hormone receptor signaling pathway  
    involved_in negative regulation of neuron differentiation  
    involved_in negative regulation of retinoic acid receptor signaling pathway  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of translation  
    involved_in negative regulation of trophoblast cell migration  
    involved_in peptide antigen assembly with MHC class I protein complex  
    acts_upstream_of positive regulation of cell cycle  
    involved_in positive regulation of cell cycle  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of dendritic cell chemotaxis  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in protein export from nucleus  
    involved_in protein folding  
    involved_in protein folding  
    involved_in protein folding PubMed 
    involved_in protein localization to nucleus  
    involved_in protein stabilization  
    involved_in protein stabilization  
    acts_upstream_of_or_within regulation of meiotic nuclear division  
    involved_in response to biphenyl PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to glycoside PubMed 
    involved_in response to peptide PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in spermatogenesis PubMed 
    Items 1 - 25 of 39
    Items 1 - 20 of 35
    Component Evidence Code Pubs
    part_of MHC class I peptide loading complex  
    located_in acrosomal vesicle PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in collagen-containing extracellular matrix PubMed 
    located_in cortical granule  
    located_in cortical granule  
    located_in cytolytic granule  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum lumen  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum quality control compartment  
    located_in external side of plasma membrane  
    located_in extracellular region  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in glutamatergic synapse PubMed 
    located_in membrane  
    located_in mitochondrion PubMed 
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in postsynapse PubMed 
    part_of protein-containing complex PubMed 
    located_in ribosome  
    located_in sarcoplasmic reticulum PubMed 
    located_in sarcoplasmic reticulum lumen  
    located_in smooth endoplasmic reticulum PubMed 
    Items 1 - 20 of 35

    General protein information

    Preferred Names
    calreticulin
    Names
    CABP3
    CALBP
    CRP55
    ERp60
    HACBP
    calcium-binding protein 3
    calregulin
    endoplasmic reticulum resident protein 60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022399.2NP_071794.1  calreticulin precursor

      See identical proteins and their annotated locations for NP_071794.1

      Status: VALIDATED

      Source sequence(s)
      AW672583, BC062395, BU671467
      UniProtKB/Swiss-Prot
      P10452, P18418
      UniProtKB/TrEMBL
      A0A8L2Q1G7, A6IY70
      Related
      ENSRNOP00000004091.6, ENSRNOT00000004091.8
      Conserved Domains (1) summary
      pfam00262
      Location:23332
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40213367..40218262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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