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    Taf10 TATA-box binding protein associated factor 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293345, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taf10provided by RGD
    Official Full Name
    TATA-box binding protein associated factor 10provided by RGD
    Primary source
    RGD:1305907
    See related
    EnsemblRapid:ENSRNOG00000019178 AllianceGenome:RGD:1305907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including identical protein binding activity; nuclear estrogen receptor binding activity; and promoter-specific chromatin binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity and histone acetyltransferase activity. Predicted to be involved in several processes, including SAGA complex assembly; chordate embryonic development; and transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; apoptotic process; and hepatocyte differentiation. Predicted to be located in male germ cell nucleus; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of SAGA-type complex; transcription factor TFIID complex; and transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human TAF10 (TATA-box binding protein associated factor 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 455.6), Thymus (RPKM 333.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Taf10 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169506940..169508234, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (160095108..160096401, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170585160..170586428, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8 Neighboring gene integrin-linked kinase Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC188059

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation  
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle  
    involved_in RNA polymerase II preinitiation complex assembly  
    involved_in SAGA complex assembly  
    involved_in allantois development  
    acts_upstream_of_or_within apoptotic process  
    involved_in biological_process  
    involved_in chromatin remodeling  
    involved_in embryonic placenta development  
    involved_in gene expression  
    acts_upstream_of_or_within hepatocyte differentiation  
    involved_in in utero embryonic development  
    involved_in lateral mesodermal cell differentiation  
    involved_in limb development  
    acts_upstream_of_or_within liver development  
    involved_in mRNA transcription by RNA polymerase II  
    acts_upstream_of_or_within multicellular organism growth  
    involved_in multicellular organism growth  
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    acts_upstream_of_or_within protein-containing complex assembly  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in somitogenesis  
    involved_in transcription initiation at RNA polymerase II promoter  
    Component Evidence Code Pubs
    part_of SAGA complex  
    located_in cytoplasm  
    located_in male germ cell nucleus  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    part_of transcription factor TFIID complex  
    part_of transcription factor TFTC complex  
    part_of transcription preinitiation complex  

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 10
    Names
    TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134735.1NP_001128207.1  transcription initiation factor TFIID subunit 10

      See identical proteins and their annotated locations for NP_001128207.1

      Status: VALIDATED

      Source sequence(s)
      BC168203
      UniProtKB/TrEMBL
      A6I7M8, B4F7B2, F7EYT0
      Related
      ENSRNOP00000025955.2, ENSRNOT00000025955.6
      Conserved Domains (1) summary
      cd07982
      Location:115217
      TAF10; The TATA Binding Protein (TBP) Associated Factor 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      169506940..169508234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106805.2XP_038962733.1  transcription initiation factor TFIID subunit 10 isoform X1

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