Ffar3 free fatty acid receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ffar3provided by RGD
Official Full Name: free fatty acid receptor 3provided by RGD
Primary source: RGD:1311035
See related: AllianceGenome:RGD:1311035
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr41
Summary: Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and cellular response to fatty acid. Predicted to be active in plasma membrane. Orthologous to several human genes including FFAR3 (free fatty acid receptor 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 1.3), Testes (RPKM 0.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95232804..95234144, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (86105388..86106728, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89302035..89304064, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Short-chain fatty acid receptors involved in epithelial acetylcholine release in rat caecum.
Title: Short-chain fatty acid receptors involved in epithelial acetylcholine release in rat caecum.
Study demonstrates that free fatty acid receptor 3 activation inhibited nicotine-evoked neural activity in the regulation of colonic motility.
Title: Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon.
These results suggest that the short-chain fatty acid-FFA3 pathway has a novel anti-secretory function in that it inhibits cholinergic neural reflexes in the enteric nervous system.
Title: Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in mucosal immune response	ISO Inferred from Sequence Orthology more info
involved_in mucosal immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart rate by chemical signal	ISO Inferred from Sequence Orthology more info
involved_in regulation of hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of hormone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of norepinephrine secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptide hormone secretion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: free fatty acid receptor 3

Names: G protein-coupled receptor 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108912.1 → NP_001102382.1 free fatty acid receptor 3

See identical proteins and their annotated locations for NP_001102382.1

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/Swiss-Prot

B2GV46

Conserved Domains (1) summary

pfam00001
Location:28 → 271

7tm_1; 7 transmembrane receptor (rhodopsin family)