Manba mannosidase beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Manbaprovided by RGD
Official Full Name: mannosidase betaprovided by RGD
Primary source: RGD:1305785
See related: EnsemblRapid:ENSRNOG00000052247 AllianceGenome:RGD:1305785
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables D-mannose binding activity and beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process and oligosaccharide catabolic process. Predicted to be located in extracellular space. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 334.2), Liver (RPKM 104.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (226583968..226676520)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (223910432..224002988)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (240668213..240760264)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH129782 (e-PCR)
- UniSTS:213074

BQ209115 (e-PCR)
- UniSTS:261752

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-mannosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-mannosidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glycoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycoprotein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligosaccharide catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal lumen	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-mannosidase

Names: lysosomal beta A mannosidase; mannanase; mannase; mannosidase beta A; mannosidase, beta A, lysosomal

NP_001026825.1

EC 3.2.1.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031655.2 → NP_001026825.1 beta-mannosidase precursor

See identical proteins and their annotated locations for NP_001026825.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q2NKP5, Q4FZV0

UniProtKB/TrEMBL

A6HVY3

Related

ENSRNOP00000072765.1, ENSRNOT00000087371.3

Conserved Domains (3) summary

COG3250
Location:24 → 694

LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

pfam02837
Location:80 → 136

Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain

cl23725
Location:397 → 568

Glyco_hydro_1; Glycosyl hydrolase family 1