RT1-S2 RT1 class Ib, locus S2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: RT1-S2provided by RGD
Official Full Name: RT1 class Ib, locus S2provided by RGD
Primary source: RGD:1595920
See related: EnsemblRapid:ENSRNOG00000032664 AllianceGenome:RGD:1595920
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RT1.S1
Summary: Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class I and immune response. Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 145.8), Lung (RPKM 47.9) and 8 other tissues See more
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Genomic context

Location:: 20p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (2655054..2664895)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (2650233..2651654)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (3152073..3165871)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of peptide antigen via MHC class I	IEA Inferred from Electronic Annotation more info
involved_in immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MHC class I protein complex	IEA Inferred from Electronic Annotation more info
located_in lumenal side of endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RT1 class Ib, locus S2

Names: RT1 class Ib gene, H2-TL-like(S2); RT1 class Ib, locus H2-TL-like (S2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008857.1 → NP_001008857.1 RT1 class Ib, locus S2 precursor

See identical proteins and their annotated locations for NP_001008857.1

Status: VALIDATED

Source sequence(s)

BX883048

UniProtKB/TrEMBL

Q6MFZ9

Related

ENSRNOP00000111191.1, ENSRNOT00000042882.6

Conserved Domains (2) summary

cd07698
Location:22 → 113

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam06623
Location:151 → 176

MHC_I_C; MHC_I C-terminus