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    Sla src-like adaptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 338477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slaprovided by RGD
    Official Full Name
    src-like adaptorprovided by RGD
    Primary source
    RGD:631373
    See related
    EnsemblRapid:ENSRNOG00000056714 AllianceGenome:RGD:631373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slap1
    Summary
    Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in endosome. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Orthologous to human SLA (Src like adaptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1551.7), Spleen (RPKM 371.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sla in Genome Data Viewer
    Location:
    7q33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (100423467..100473840, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (98534431..98584810, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (107585055..107604950, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20-like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene thyroglobulin Neighboring gene cellular communication network factor 4 Neighboring gene N-myc downstream regulated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Restricted expression of Slap-1 in the rodent cerebral cortex. Alifragis P, et al. Gene Expr Patterns, 2003 Aug. PMID 12915308
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    src-like-adapter
    Names
    SLAP-1
    src-like-adapter protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178097.3 → NP_835198.2  src-like-adapter

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K3G1, A0A0G2KAQ1, A0A1W2Q6L4, A6HRR8
      Related
      ENSRNOP00000072624.2, ENSRNOT00000087116.3
      Conserved Domains (2) summary
      cd10344
      Location:89 → 186
      SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
      cd12010
      Location:42 → 96
      SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      100423467..100473840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079357.2 → XP_038935285.1  src-like-adapter isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAQ1, A6HRR9
      Conserved Domains (2) summary
      cd10344
      Location:73 → 170
      SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
      cd12010
      Location:26 → 80
      SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

    2. XM_063263691.1 → XP_063119761.1  src-like-adapter isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAQ1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59622.1 GenPept UniProtKB/Swiss-Prot:P59622

    Gene LinkOut

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