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    Lsr lipolysis stimulated lipoprotein receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64355, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lsrprovided by RGD
    Official Full Name
    lipolysis stimulated lipoprotein receptorprovided by RGD
    Primary source
    RGD:69236
    See related
    EnsemblRapid:ENSRNOG00000021053 AllianceGenome:RGD:69236
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lisch7
    Summary
    Predicted to enable fatty acid binding activity and triglyceride binding activity. Involved in regulation of lipid metabolic process. Predicted to be located in tight junction. Predicted to be part of chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in plasma membrane and tricellular tight junction. Orthologous to human LSR (lipolysis stimulated lipoprotein receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 220.7), Kidney (RPKM 131.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lsr in Genome Data Viewer
    Location:
    1q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95313830..95329471, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86185769..86201952, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89383515..89399041, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099789 Neighboring gene myelin-associated glycoprotein Neighboring gene hepcidin antimicrobial peptide Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene family with sequence similarity 187, member B Neighboring gene uncharacterized LOC134483094 Neighboring gene uncharacterized LOC134483095

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC124592

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in epithelial structure maintenance  
    involved_in epithelial structure maintenance  
    involved_in establishment of blood-brain barrier  
    involved_in establishment of blood-brain barrier  
    involved_in establishment of skin barrier  
    involved_in liver development  
    involved_in liver development  
    involved_in protein localization to tricellular tight junction  
    involved_in regulation of lipid metabolic process PubMed 
    involved_in tricellular tight junction assembly  
    involved_in tricellular tight junction assembly  
    Component Evidence Code Pubs
    located_in bicellular tight junction  
    located_in cell junction  
    part_of chylomicron  
    located_in endomembrane system  
    part_of low-density lipoprotein particle  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in tight junction  
    located_in tight junction  
    is_active_in tricellular tight junction  
    located_in tricellular tight junction  
    part_of very-low-density lipoprotein particle  

    General protein information

    Preferred Names
    lipolysis-stimulated lipoprotein receptor
    Names
    lipolysis-stimulated receptor
    lipolysis-stimulated remnant receptor
    liver-specific bHLH-Zip transcription factor 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032616.2NP_116005.1  lipolysis-stimulated lipoprotein receptor precursor

      See identical proteins and their annotated locations for NP_116005.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q497B9, Q9WU74, Q9WU75, Q9WU76
      UniProtKB/TrEMBL
      A0A8I6GKQ0, A6JA42
      Related
      ENSRNOP00000041379.2, ENSRNOT00000044678.7
      Conserved Domains (1) summary
      pfam12871
      Location:470531
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95313830..95329471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228845.5XP_006228907.1  lipolysis-stimulated lipoprotein receptor isoform X2

      See identical proteins and their annotated locations for XP_006228907.1

      UniProtKB/TrEMBL
      A0A8I6GKQ0, A6JA40
      Related
      ENSRNOP00000097477.1, ENSRNOT00000116572.2
      Conserved Domains (1) summary
      pfam12871
      Location:402463
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    2. XM_006228844.5XP_006228906.1  lipolysis-stimulated lipoprotein receptor isoform X1

      See identical proteins and their annotated locations for XP_006228906.1

      UniProtKB/TrEMBL
      A0A8I6GKQ0, A6JA41
      Related
      ENSRNOP00000028585.4, ENSRNOT00000028585.9
      Conserved Domains (2) summary
      pfam08648
      Location:451512
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:451512
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
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