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    Fgd4 FYVE, RhoGEF and PH domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246174, updated on 9-Dec-2024

    Summary

    Symbol
    Fgd4provided by RGD
    Full Name
    FYVE, RhoGEF and PH domain containing 4provided by RGD
    Primary source
    RGD:708357
    See related
    EnsemblRapid:ENSRNOG00000059491 AllianceGenome:RGD:708357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables actin filament binding activity. Involved in positive regulation of JNK cascade and regulation of cell shape. Acts upstream of or within positive regulation of JUN kinase activity. Predicted to be located in filopodium and lamellipodium. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 128.0), Kidney (RPKM 96.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fgd4 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97904182..98055190)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (84399989..84551013)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88699222..88796677)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546862 Neighboring gene olfactory receptor 19-like Neighboring gene ribosomal protein S27a, pseudogene 23 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene dynamin 1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding PubMed 
    enables actin filament binding PubMed 
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables metal ion binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in filopodium  
    located_in filopodium  
    located_in lamellipodium  
    located_in lamellipodium  

    General protein information

    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein 4
    Names
    FGD1-related F-actin-binding protein
    actin filament-binding protein frabin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415054.1NP_001401983.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0G2K2S8, A6JSP9
      Related
      ENSRNOP00000072359.2, ENSRNOT00000078367.3
    2. NM_001415055.1NP_001401984.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      O88387
      UniProtKB/TrEMBL
      A0A0G2K8X0, A6JSQ0
      Related
      ENSRNOP00000100627.1, ENSRNOT00000145334.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      97904182..98055190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087982.2XP_038943910.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GK89, A6JSP9
      Related
      ENSRNOP00000092594.1, ENSRNOT00000100508.2
      Conserved Domains (4) summary
      cd00160
      Location:281465
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:711813
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:497590
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:628692
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    2. XM_039087984.2XP_038943912.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X2

      UniProtKB/Swiss-Prot
      O88387
      UniProtKB/TrEMBL
      A0A0G2K8X0, A6JSQ0
      Conserved Domains (4) summary
      cd00160
      Location:207391
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:637739
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:423516
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:554618
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    3. XM_063270283.1XP_063126353.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X3

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