Itga7 integrin subunit alpha 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itga7provided by RGD
Official Full Name: integrin subunit alpha 7provided by RGD
Primary source: RGD:71022
See related: EnsemblRapid:ENSRNOG00000007905 AllianceGenome:RGD:71022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables integrin binding activity and laminin binding activity. Involved in cell adhesion; integrin-mediated signaling pathway; and skeletal muscle tissue development. Located in cell surface. Part of integrin complex. Used to study cardiomyopathy. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; and muscular disease. Orthologous to human ITGA7 (integrin subunit alpha 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 601.6), Muscle (RPKM 166.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1944447..1973347)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (1360125..1388886)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (3355079..3383886)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The laminin-binding integrin alpha7beta1 is oxidized by hydrogen peroxide at specific sites and thereby redox regulated in its binding activity.
Title: Integrin α7β1 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesion.
alpha7beta1 integrin is a Schwann cell receptor for laminin-2.
Title: Alpha7beta1 integrin is a receptor for laminin-2 on Schwann cells.
Alpha(7)beta(1) integrin is a potential receptor for COMP. The protective effects of COMP are mainly mediated through interaction with alpha(7)beta(1) integrin.
Title: Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.
cleavage is a novel mechanism that regulates alpha7 integrin functions in skeletal muscle, and that the generation of such cleavage sites is another evolutionary mechanism for expanding and modifying protein functions.
Title: Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function.
the distribution of alpha 7 integrins in series-fibred muscles suggests they are involved in transmission of tension from intrafascicularly terminating fibres to neighbouring fibres
Title: Localization of alpha 7 integrins and dystrophin suggests potential for both lateral and longitudinal transmission of tension in large mammalian muscles.
Chemical injury induced by allylamine significantly enhances alpha(7)-integrin expression in vascular smooth muscle cells.
Title: Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis.
Results indicate that platelet-derived growth factor enhances alpha(7)-integrin expression in vascular smooth muscle cells and promotes alpha(7)-integrin-mediated adhesion to laminin.
Title: Modulation of alpha7-integrin-mediated adhesion and expression by platelet-derived growth factor in vascular smooth muscle cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itga7 (e-PCR), detects polymorphism
- UniSTS:143624

RH128213 (e-PCR)
- UniSTS:211521

Itga7 (e-PCR), detects polymorphism
- UniSTS:256617

D0Uia20 (e-PCR)
- UniSTS:518861

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables laminin binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to laminin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in endodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alpha7-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in muscle tendon junction	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-7

Names: H36-alpha7; alpha 7A integrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429169.1 → NP_001416098.1 integrin alpha-7 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2QS22
NM_001429170.1 → NP_001416099.1 integrin alpha-7 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2QS22, A6KSK9
NM_001429171.1 → NP_001416100.1 integrin alpha-7 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2QS22
NM_001429172.1 → NP_001416101.1 integrin alpha-7 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2QS22
NM_001429174.1 → NP_001416103.1 integrin alpha-7 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2QS22
NM_030842.2 → NP_110469.1 integrin alpha-7 isoform 4 precursor

See identical proteins and their annotated locations for NP_110469.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q5HZX9, Q63026, Q63027, Q63258

UniProtKB/TrEMBL

A0A8L2QS22, A6KSL0

Conserved Domains (2) summary

smart00191
Location:377 → 429

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:471 → 960

Integrin_alpha2; Integrin alpha