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    Slc4a10 solute carrier family 4 member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295645, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc4a10provided by RGD
    Official Full Name
    solute carrier family 4 member 10provided by RGD
    Primary source
    RGD:631407
    See related
    EnsemblRapid:ENSRNOG00000005307 AllianceGenome:RGD:631407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NCBE
    Summary
    Enables sodium,bicarbonate:chloride antiporter activity and sodium:bicarbonate symporter activity. Predicted to be involved in several processes, including bicarbonate transport; regulation of short-term neuronal synaptic plasticity; and visual perception. Predicted to act upstream of or within several processes, including brain development; locomotory exploration behavior; and proton transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC4A10 (solute carrier family 4 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 349.2) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc4a10 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (67050925..67367637)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (46665076..46959088)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (47995812..48287897)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 249 Neighboring gene ribosomal protein L9, pseudogene 12 Neighboring gene uncharacterized LOC134486365 Neighboring gene dipeptidylpeptidase 4 Neighboring gene uncharacterized LOC120101554 Neighboring gene uncharacterized LOC103691814

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in bicarbonate transport  
    involved_in bicarbonate transport  
    involved_in brain morphogenesis  
    acts_upstream_of_or_within brain morphogenesis  
    involved_in inorganic anion transport  
    involved_in locomotory exploration behavior  
    acts_upstream_of_or_within locomotory exploration behavior  
    involved_in monoatomic anion transmembrane transport  
    involved_in multicellular organism growth  
    acts_upstream_of_or_within multicellular organism growth  
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    involved_in proton transmembrane transport  
    acts_upstream_of_or_within proton transmembrane transport  
    involved_in pyramidal neuron development  
    acts_upstream_of_or_within pyramidal neuron development  
    involved_in regulation of cellular pH  
    acts_upstream_of_or_within regulation of cellular pH  
    involved_in regulation of intracellular pH  
    acts_upstream_of_or_within regulation of pH  
    involved_in regulation of short-term neuronal synaptic plasticity  
    involved_in regulation of short-term neuronal synaptic plasticity  
    involved_in regulation of short-term neuronal synaptic plasticity  
    involved_in response to light stimulus  
    acts_upstream_of_or_within response to light stimulus  
    involved_in sodium ion transmembrane transport  
    involved_in transmembrane transport  
    involved_in visual perception  
    involved_in visual perception  
    involved_in visual perception  
    Items 1 - 25 of 30
    Items 1 - 20 of 31
    Component Evidence Code Pubs
    located_in CA3 pyramidal cell dendrite  
    located_in CA3 pyramidal cell dendrite  
    located_in GABA-ergic synapse  
    located_in GABA-ergic synapse  
    located_in GABA-ergic synapse  
    located_in apical dendrite  
    located_in apical dendrite  
    located_in apical plasma membrane PubMed 
    located_in axon terminus  
    located_in axon terminus  
    located_in axon terminus  
    located_in basal dendrite  
    located_in basal dendrite  
    is_active_in basolateral plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in dendrite  
    located_in dendrite  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    located_in somatodendritic compartment  
    located_in somatodendritic compartment  
    located_in synapse  
    located_in synapse  
    Items 1 - 20 of 31

    General protein information

    Preferred Names
    sodium-driven chloride bicarbonate exchanger
    Names
    Na+ bicarbonate transporter NBCn2-G
    Na-bicarbonate cotransporter NBCn2-O
    solute carrier family 4, sodium bicarbonate transporter, member 10
    solute carrier family 4, sodium bicarbonate transporter-like, member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429835.1NP_001416764.1  sodium-driven chloride bicarbonate exchanger isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6GM66
    2. NM_001429836.1NP_001416765.1  sodium-driven chloride bicarbonate exchanger isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2QND6
    3. NM_001429837.1NP_001416766.1  sodium-driven chloride bicarbonate exchanger isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6GM66
    4. NM_178092.3NP_835193.1  sodium-driven chloride bicarbonate exchanger isoform 4

      See identical proteins and their annotated locations for NP_835193.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      A0A0G2JYF0, A0A2L1K0J5, D3ZGB5, D3ZY00, D4ADV4, J7FMV4, J7FPF5, J7FRI2, J7FTX0, Q6PU70, Q6PU71, Q6PU72, Q6PU73, Q6PU74, Q80ZA5, Q80ZA6
      UniProtKB/TrEMBL
      A0A8I6GM66
      Related
      ENSRNOP00000007218.8, ENSRNOT00000007218.9
      Conserved Domains (3) summary
      TIGR00834
      Location:1181060
      ae; anion exchange protein
      pfam00955
      Location:475988
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:146434
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      67050925..67367637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283270.1XP_063139340.1  sodium-driven chloride bicarbonate exchanger isoform X10

      UniProtKB/TrEMBL
      A0A8I6A5G1, W0NXI0
      Related
      ENSRNOP00000059155.3, ENSRNOT00000067545.6
    2. XM_006234283.5XP_006234345.1  sodium-driven chloride bicarbonate exchanger isoform X9

      See identical proteins and their annotated locations for XP_006234345.1

      UniProtKB/TrEMBL
      A0A8I6GM66
      Conserved Domains (3) summary
      TIGR00834
      Location:1181030
      ae; anion exchange protein
      pfam00955
      Location:445958
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:146404
      Band_3_cyto; Band 3 cytoplasmic domain
    3. XM_006234277.5XP_006234339.1  sodium-driven chloride bicarbonate exchanger isoform X2

      Related
      ENSRNOP00000071402.2, ENSRNOT00000087711.3
      Conserved Domains (3) summary
      TIGR00834
      Location:1181061
      ae; anion exchange protein
      pfam00955
      Location:476989
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:146435
      Band_3_cyto; Band 3 cytoplasmic domain
    4. XM_006234282.5XP_006234344.1  sodium-driven chloride bicarbonate exchanger isoform X8

      Conserved Domains (3) summary
      TIGR00834
      Location:1181031
      ae; anion exchange protein
      pfam00955
      Location:446959
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:146405
      Band_3_cyto; Band 3 cytoplasmic domain
    5. XM_063283269.1XP_063139339.1  sodium-driven chloride bicarbonate exchanger isoform X3

      UniProtKB/TrEMBL
      A0A8I6GM66
    6. XM_006234275.5XP_006234337.1  sodium-driven chloride bicarbonate exchanger isoform X4

      UniProtKB/TrEMBL
      A0A8L2QND6
      Conserved Domains (3) summary
      TIGR00834
      Location:1301073
      ae; anion exchange protein
      pfam00955
      Location:4881001
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:158447
      Band_3_cyto; Band 3 cytoplasmic domain
    7. XM_063283271.1XP_063139341.1  sodium-driven chloride bicarbonate exchanger isoform X12

      Related
      ENSRNOP00000086142.2, ENSRNOT00000104570.2
    8. XM_039104485.2XP_038960413.1  sodium-driven chloride bicarbonate exchanger isoform X11

      UniProtKB/TrEMBL
      A6HLV1
      Conserved Domains (1) summary
      cl26877
      Location:130859
      Band_3_cyto; Band 3 cytoplasmic domain
    9. XM_006234276.5XP_006234338.1  sodium-driven chloride bicarbonate exchanger isoform X1

      Conserved Domains (3) summary
      TIGR00834
      Location:1301072
      ae; anion exchange protein
      pfam00955
      Location:4871000
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:158446
      Band_3_cyto; Band 3 cytoplasmic domain
    10. XM_017591546.3XP_017447035.1  sodium-driven chloride bicarbonate exchanger isoform X7

      UniProtKB/TrEMBL
      A0A097PID6, A0A8L2QND6
      Conserved Domains (3) summary
      TIGR00834
      Location:1301042
      ae; anion exchange protein
      pfam00955
      Location:457970
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:158416
      Band_3_cyto; Band 3 cytoplasmic domain
    11. XM_006234280.5XP_006234342.1  sodium-driven chloride bicarbonate exchanger isoform X6

      See identical proteins and their annotated locations for XP_006234342.1

      UniProtKB/TrEMBL
      A0A8L2QND6
      Related
      ENSRNOP00000059915.4, ENSRNOT00000064344.6
      Conserved Domains (3) summary
      TIGR00834
      Location:1301043
      ae; anion exchange protein
      pfam00955
      Location:458971
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:158417
      Band_3_cyto; Band 3 cytoplasmic domain
    12. XM_017591545.3XP_017447034.1  sodium-driven chloride bicarbonate exchanger isoform X5

      UniProtKB/TrEMBL
      D4AD03
      Related
      ENSRNOP00000062481.3, ENSRNOT00000068238.4
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