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    Pigg phosphatidylinositol glycan anchor biosynthesis, class G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910143, updated on 9-Dec-2024

    Summary

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    Symbol
    Piggprovided by RGD
    Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Gprovided by RGD
    Primary source
    RGD:1560335
    See related
    EnsemblRapid:ENSRNOG00000071170 AllianceGenome:RGD:1560335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560335
    Summary
    Predicted to enable CP2 mannose-ethanolamine phosphotransferase activity. Predicted to act upstream of or within GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Orthologous to human PIGG (phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 108.5), Kidney (RPKM 105.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pigg in Genome Data Viewer
    Location:
    14p22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (1549891..1578174, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1404911..1433199, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (1567713..1596004, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene transmembrane protein 271 Neighboring gene down-regulator of transcription 1 Neighboring gene coiled-coil domain containing 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. Shishioh N, et al. J Biol Chem, 2005 Mar 11. PMID 15632136
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CP2 mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CP2 mannose-ethanolamine phosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI ethanolamine phosphate transferase 2
    Names
    GPI ethanolamine phosphate transferase 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427662.1 → NP_001414591.1  GPI ethanolamine phosphate transferase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KPG3, M0R9J2
      Related
      ENSRNOP00000066161.2, ENSRNOT00000075415.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      1549891..1578174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250517.5 → XP_006250579.1  GPI ethanolamine phosphate transferase 2 isoform X4

      See identical proteins and their annotated locations for XP_006250579.1

      UniProtKB/TrEMBL
      A6KPG3
      Conserved Domains (2) summary
      COG1524
      Location:45 → 311
      Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
      cd16024
      Location:62 → 335
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

    2. XM_006250514.5 → XP_006250576.1  GPI ethanolamine phosphate transferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006250576.1

      UniProtKB/TrEMBL
      A6KPG3, M0RDM7
      Related
      ENSRNOP00000067732.3, ENSRNOT00000072386.4
      Conserved Domains (2) summary
      COG1524
      Location:45 → 311
      Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
      cd16024
      Location:62 → 335
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

    3. XM_006250515.5 → XP_006250577.1  GPI ethanolamine phosphate transferase 2 isoform X2

      See identical proteins and their annotated locations for XP_006250577.1

      UniProtKB/TrEMBL
      A6KPG3
      Conserved Domains (1) summary
      cd16024
      Location:1 → 265
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

    4. XM_039092608.2 → XP_038948536.1  GPI ethanolamine phosphate transferase 2 isoform X6

      Conserved Domains (1) summary
      cl23718
      Location:1 → 97
      ALP_like; alkaline phosphatases and sulfatases

    5. XM_063272800.1 → XP_063128870.1  GPI ethanolamine phosphate transferase 2 isoform X5

    6. XM_006250516.5 → XP_006250578.1  GPI ethanolamine phosphate transferase 2 isoform X3

      See identical proteins and their annotated locations for XP_006250578.1

      UniProtKB/TrEMBL
      A6KPG3
      Conserved Domains (1) summary
      cd16024
      Location:62 → 335
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G

    RNA

    1. XR_005493074.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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