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    Zc3h7a zinc finger CCCH type containing 7 A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360466, updated on 9-Dec-2024

    Summary

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    Symbol
    Zc3h7aprovided by RGD
    Full Name
    zinc finger CCCH type containing 7 Aprovided by RGD
    Primary source
    RGD:1311225
    See related
    EnsemblRapid:ENSRNOG00000002420 AllianceGenome:RGD:1311225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zc3hdc7
    Summary
    Predicted to enable miRNA binding activity. Predicted to be involved in miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be located in nucleus. Orthologous to human ZC3H7A (zinc finger CCCH-type containing 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 242.7), Spleen (RPKM 187.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zc3h7a in Genome Data Viewer
    Location:
    10q11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (4980147..5019637)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4473177..4512668)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4535651..4575643)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911627 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene uncharacterized LOC134480745 Neighboring gene thioredoxin domain containing 11 Neighboring gene BCL2 like 12, pseudogene 2 Neighboring gene stannin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Treiber T, et al. Mol Cell, 2017 Apr 20. PMID 28431233
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 7A
    Names
    zinc finger CCCH type domain containing 7
    zinc finger CCCH-type containing 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108262.2 → NP_001101732.2  zinc finger CCCH domain-containing protein 7A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZP12
      Related
      ENSRNOP00000108427.1, ENSRNOT00000150174.1
      Conserved Domains (4) summary
      TIGR00990
      Location:46 → 169
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00020
      Location:859 → 881
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:857 → 882
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      4980147..5019637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269282.1 → XP_063125352.1  zinc finger CCCH domain-containing protein 7A isoform X2

      UniProtKB/TrEMBL
      A6K4H8

    2. XM_008767490.4 → XP_008765712.1  zinc finger CCCH domain-containing protein 7A isoform X1

      See identical proteins and their annotated locations for XP_008765712.1

      UniProtKB/TrEMBL
      D3ZP12
      Related
      ENSRNOP00000003309.7, ENSRNOT00000003309.9
      Conserved Domains (4) summary
      TIGR00990
      Location:46 → 169
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00020
      Location:859 → 881
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:857 → 882
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    3. XM_063269280.1 → XP_063125350.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/TrEMBL
      D3ZP12

    4. XM_063269281.1 → XP_063125351.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/TrEMBL
      D3ZP12

    5. XM_039086257.2 → XP_038942185.1  zinc finger CCCH domain-containing protein 7A isoform X3

      Conserved Domains (2) summary
      sd00020
      Location:468 → 490
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:466 → 491
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RNA

    1. XR_594546.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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