Slc29a3 solute carrier family 29 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc29a3provided by RGD
Official Full Name: solute carrier family 29 member 3provided by RGD
Primary source: RGD:727811
See related: EnsemblRapid:ENSRNOG00000000568 AllianceGenome:RGD:727811
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ent3; rENT3
Summary: Enables nucleoside transmembrane transporter activity. Involved in nucleoside transport. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to human SLC29A3 (solute carrier family 29 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 207.0), Spleen (RPKM 48.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (29191086..29228299, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (28645265..28685388, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (30289527..30327343, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytidine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables cytidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cytidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables guanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables guanine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoamine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleobase transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleobase transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables nucleoside transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleoside transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables uracil transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uracil transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uracil transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables uridine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenosine transport	IEA Inferred from Electronic Annotation more info
involved_in adenosine transport	ISO Inferred from Sequence Orthology more info
involved_in adenosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytidine transport	IEA Inferred from Electronic Annotation more info
involved_in cytidine transport	ISO Inferred from Sequence Orthology more info
involved_in cytidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in dopamine transport	IEA Inferred from Electronic Annotation more info
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in guanine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in guanine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inosine transport	IEA Inferred from Electronic Annotation more info
involved_in inosine transport	ISO Inferred from Sequence Orthology more info
involved_in inosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine transport	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleobase transport	ISO Inferred from Sequence Orthology more info
involved_in nucleobase transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyrimidine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in serotonin transport	IEA Inferred from Electronic Annotation more info
involved_in serotonin transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in uracil transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uracil transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uracil transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in uridine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: equilibrative nucleoside transporter 3

Names: solute carrier family 29 (equilibrative nucleoside transporter), member 3; solute carrier family 29 (nucleoside transporters), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181639.3 → NP_853670.2 equilibrative nucleoside transporter 3

Status: PROVISIONAL

Source sequence(s)

BC078678

UniProtKB/Swiss-Prot

Q6AZ86, Q80WK7

UniProtKB/TrEMBL

A0A8I6GLJ6, A6K3Y0

Related

ENSRNOP00000082643.1, ENSRNOT00000113968.2

Conserved Domains (1) summary

cl15430
Location:57 → 475

Nucleoside_tran; Nucleoside transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

29191086..29228299 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098779.2 → XP_038954707.1 equilibrative nucleoside transporter 3 isoform X1

Conserved Domains (1) summary

cl15430
Location:1 → 269

Nucleoside_tran; Nucleoside transporter