Baz1b bromodomain adjacent to zinc finger domain, 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Baz1bprovided by RGD
Official Full Name: bromodomain adjacent to zinc finger domain, 1Bprovided by RGD
Primary source: RGD:1597089
See related: EnsemblRapid:ENSRNOG00000001453 AllianceGenome:RGD:1597089
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone H2AXY142 kinase activity and histone binding activity. Predicted to be involved in several processes, including negative regulation of mitotic chromosome condensation; positive regulation of transcription by RNA polymerase III; and post-translational protein modification. Predicted to act upstream of or within chromatin organization. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of B-WICH complex and WICH complex. Orthologous to human BAZ1B (bromodomain adjacent to zinc finger domain 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 256.0), Thymus (RPKM 247.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27068541..27126511, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (21431985..21489956, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (24478882..24536851, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF388132 (e-PCR)
- UniSTS:260934

Baz1b (e-PCR), detects polymorphism
- UniSTS:144766

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H2AXY142 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of B-WICH complex	ISO Inferred from Sequence Orthology more info
part_of WICH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WICH complex	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase BAZ1B

Names: bromodomain adjacent to zinc finger domain protein 1B

NP_001178845.1

EC 2.7.10.2

XP_038945581.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191916.1 → NP_001178845.1 tyrosine-protein kinase BAZ1B

See identical proteins and their annotated locations for NP_001178845.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I6ALC2, A6J0E2, G3V661

Related

ENSRNOP00000094596.1, ENSRNOT00000100108.2

Conserved Domains (7) summary

cd05505
Location:1337 → 1433

Bromo_WSTF_like; Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two ...

smart00571
Location:602 → 666

DDT; domain in different transcription and chromosome remodeling factors

cd15628
Location:1183 → 1228

PHD_BAZ1B; PHD finger found in bromodomain adjacent to zinc finger domain protein 1B (BAZ1B)

pfam10537
Location:21 → 120

WAC_Acf1_DNA_bd; ATP-utilizing chromatin assembly and remodelling N-terminal

pfam15612
Location:722 → 771

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:897 → 925

WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2

pfam15614
Location:988 → 1026

WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

27068541..27126511 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089653.2 → XP_038945581.1 tyrosine-protein kinase BAZ1B isoform X1

UniProtKB/TrEMBL

G3V661

Conserved Domains (7) summary

cd05505
Location:1040 → 1136

Bromo_WSTF_like; Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two ...

smart00571
Location:305 → 369

DDT; domain in different transcription and chromosome remodeling factors

cd15628
Location:886 → 931

PHD_BAZ1B; PHD finger found in bromodomain adjacent to zinc finger domain protein 1B (BAZ1B)

pfam17380
Location:464 → 562

DUF5401; Family of unknown function (DUF5401)

pfam15612
Location:428 → 468

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:599 → 725

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

pfam15709
Location:210 → 270

DUF4670; Domain of unknown function (DUF4670)