Myo18b myosin XVIIIb [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Myo18bprovided by RGD
Full Name: myosin XVIIIbprovided by RGD
Primary source: RGD:1594542
See related: EnsemblRapid:ENSRNOG00000048430 AllianceGenome:RGD:1594542
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within cardiac muscle cell development; in utero embryonic development; and vasculogenesis. Predicted to be located in Z disc. Predicted to be part of filamentous actin; myosin II complex; and unconventional myosin complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 4. Orthologous to human MYO18B (myosin XVIIIB). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 576.1) and Heart (RPKM 200.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (49421062..49614127)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (43747003..43953694)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (49761100..49979745)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF414070 (e-PCR)
- UniSTS:248688

Myo18b (e-PCR), detects polymorphism
- UniSTS:257232

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
part_of unconventional myosin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of unconventional myosin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin XVIIIb; unconventional myosin-XVIIIb

Names: unconventional myosin-XVIIIb-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.