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    Zbtb4 zinc finger and BTB domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287441, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zbtb4provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 4provided by RGD
    Primary source
    RGD:1307184
    See related
    EnsemblRapid:ENSRNOG00000014689 AllianceGenome:RGD:1307184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleotide binding activity; and protein homodimerization activity. Predicted to be involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear body. Orthologous to human ZBTB4 (zinc finger and BTB domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 186.3), Brain (RPKM 148.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Zbtb4 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54979421..55000215)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54480698..54501492)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56367586..56388296)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 19 Neighboring gene RNA polymerase II subunit A Neighboring gene solute carrier family 35, member G3 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene fibroblast growth factor 11 Neighboring gene transmembrane protein 102

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromosome  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304352.1NP_001291281.1  zinc finger and BTB domain-containing protein 4

      See identical proteins and their annotated locations for NP_001291281.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D4A8X0
      Related
      ENSRNOP00000019687.4, ENSRNOT00000019687.8
      Conserved Domains (6) summary
      sd00017
      Location:287307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18195
      Location:12160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam00096
      Location:736758
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:341364
      zf-C2H2_4; C2H2-type zinc finger
      pfam13913
      Location:211233
      zf-C2HC_2; zinc-finger of a C2HC-type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54979421..55000215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246844.4XP_006246906.1  zinc finger and BTB domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006246906.1

      UniProtKB/Swiss-Prot
      D4A8X0
      Conserved Domains (6) summary
      sd00017
      Location:287307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18195
      Location:12160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam00096
      Location:736758
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:341364
      zf-C2H2_4; C2H2-type zinc finger
      pfam13913
      Location:211233
      zf-C2HC_2; zinc-finger of a C2HC-type
    2. XM_039085459.2XP_038941387.1  zinc finger and BTB domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      D4A8X0
      Conserved Domains (6) summary
      sd00017
      Location:287307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:212228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18195
      Location:12160
      BTB_POZ_ZBTB4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4)
      pfam00096
      Location:736758
      zf-C2H2; Zinc finger, C2H2 type
      pfam13894
      Location:341364
      zf-C2H2_4; C2H2-type zinc finger
      pfam13913
      Location:211233
      zf-C2HC_2; zinc-finger of a C2HC-type
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