Dusp11 dual specificity phosphatase 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dusp11provided by RGD
Full Name: dual specificity phosphatase 11provided by RGD
Primary source: RGD:1307038
See related: EnsemblRapid:ENSRNOG00000045539 AllianceGenome:RGD:1307038
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity; polynucleotide 5'-phosphatase activity; and protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in intercellular bridge; mitochondrion; and nuclear lumen. Orthologous to human DUSP11 (dual specificity phosphatase 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 195.0), Spleen (RPKM 194.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (119928533..119942643, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (118367673..118385183, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (117617640..117631674, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables polynucleotide 5'-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables polynucleotide 5'-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables polynucleotide 5'-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA/RNP complex-1-interacting phosphatase

Names: RNA/RNP complex-1-interacting phosphatase-like; dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); dual specificity protein phosphatase 11; phosphatase that interacts with RNA/RNP complex 1

NP_001020821.1

EC 3.1.3.48

XP_063141881.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025650.1 → NP_001020821.1 RNA/RNP complex-1-interacting phosphatase

See identical proteins and their annotated locations for NP_001020821.1

Status: PROVISIONAL

Source sequence(s)

BC098712

UniProtKB/Swiss-Prot

Q4KM79

UniProtKB/TrEMBL

A0A8I6AJJ6, A6IAU5

Related

ENSRNOP00000054285.2, ENSRNOT00000057475.6

Conserved Domains (1) summary

cl21483
Location:77 → 194

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...