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    Gng12 G protein subunit gamma 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gng12provided by RGD
    Official Full Name
    G protein subunit gamma 12provided by RGD
    Primary source
    RGD:621516
    See related
    AllianceGenome:RGD:621516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg3a
    Summary
    Enables phosphate ion binding activity. Involved in cerebral cortex development and response to lipopolysaccharide. Located in actin filament. Orthologous to human GNG12 (G protein subunit gamma 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 174.9), Adrenal (RPKM 104.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gng12 in Genome Data Viewer
    Location:
    4q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (97340830..97464422)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (96011118..96134767)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (97634925..97763478)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene mitotic arrest deficient 2 like 1 Neighboring gene vomeronasal 1 receptor 89 Neighboring gene uncharacterized LOC100912188 Neighboring gene growth arrest and DNA-damage-inducible, alpha Neighboring gene uncharacterized LOC120102291 Neighboring gene Serpine1 mRNA binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GTP-binding protein gamma12 subunit phosphorylation by protein kinase C--identification of the phosphorylation site and factors involved in cultured cells and rat tissues in vivo. Asano T, et al. Eur J Biochem, 1998 Jan 15. PMID 9492299
    2. Gng12 is a novel negative regulator of LPS-induced inflammation in the microglial cell line BV-2. Larson KC, et al. Inflamm Res, 2010 Jan. PMID 19568691
    3. Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. Morishita R, et al. J Neurochem, 1997 Feb. PMID 9003074
    4. Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain. Betty M, et al. Neuroscience, 1998 Jul. PMID 9622245
    5. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphate ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
    Names
    guanine nucleotide binding protein (G protein), gamma 12
    heterotrimeric guanine nucleotide-binding protein 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053661.1 → NP_446113.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

      See identical proteins and their annotated locations for NP_446113.1

      Status: VALIDATED

      Source sequence(s)
      BG378509, FM031435
      UniProtKB/TrEMBL
      A6KF41, G3V6P8
      Conserved Domains (1) summary
      smart00224
      Location:12 → 72
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      97340830..97464422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285384.1 → XP_063141454.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

      UniProtKB/TrEMBL
      A6KF41, G3V6P8

    2. XM_039106904.2 → XP_038962832.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

      UniProtKB/TrEMBL
      A6KF41, G3V6P8
      Conserved Domains (1) summary
      smart00224
      Location:12 → 72
      GGL; G protein gamma subunit-like motifs

    3. XM_063285385.1 → XP_063141455.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

      UniProtKB/TrEMBL
      A6KF41, G3V6P8

    4. XM_063285387.1 → XP_063141457.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

      UniProtKB/TrEMBL
      A6KF41, G3V6P8

    5. XM_063285386.1 → XP_063141456.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

      UniProtKB/TrEMBL
      A6KF41, G3V6P8
    Nucleotide Protein Strain
    Heading Accession and Version

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